Fields »
ABOUT
HELP
BLOG
ACADVL

GENERAL INFORMATION

Gene name

 ACADVL

Gene description

 Acyl-CoA dehydrogenase, very long chain

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA019006 , HPA020595
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ACADVL (HGNC Symbol)

Synonyms

 ACAD6, LCACD, VLCAD

Description

 Acyl-CoA dehydrogenase, very long chain (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7217125 - 7225273

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072778 (version 83.38)

Entrez gene

 37

UniProt

 P49748 (UniProt - Evidence at protein level)

neXtProt

 NX_P49748

Antibodypedia

 ACADVL antibodies

PROTEIN BROWSER
ACADVL-001
ACADVL-002
ACADVL-007
ACADVL-015
ACADVL-024
ACADVL-037
ACADVL-040
ACADVL-041

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACADVL-001
ENSP00000349297
ENST00000356839
P49748 [Direct mapping]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0001659 [temperature homeostasis]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0004466 [long-chain-acyl-CoA dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0015980 [energy derivation by oxidation of organic compounds]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0017099 [very-long-chain-acyl-CoA dehydrogenase activity]
GO:0030855 [epithelial cell differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042645 [mitochondrial nucleoid]
GO:0042760 [very long-chain fatty acid catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0046322 [negative regulation of fatty acid oxidation]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0090181 [regulation of cholesterol metabolic process]
Show all
 655 aa
70.4 kDa 		No 0
ACADVL-002
ENSP00000344152
ENST00000350303
P49748 [Direct mapping]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0001659 [temperature homeostasis]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0004466 [long-chain-acyl-CoA dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0015980 [energy derivation by oxidation of organic compounds]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0017099 [very-long-chain-acyl-CoA dehydrogenase activity]
GO:0030855 [epithelial cell differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042645 [mitochondrial nucleoid]
GO:0042760 [very long-chain fatty acid catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0046322 [negative regulation of fatty acid oxidation]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0090181 [regulation of cholesterol metabolic process]
Show all
 633 aa
68.1 kDa 		No 0
ACADVL-007
ENSP00000438689
ENST00000543245
P49748 [Direct mapping]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0001659 [temperature homeostasis]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0004466 [long-chain-acyl-CoA dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0015980 [energy derivation by oxidation of organic compounds]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0017099 [very-long-chain-acyl-CoA dehydrogenase activity]
GO:0030855 [epithelial cell differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042645 [mitochondrial nucleoid]
GO:0042760 [very long-chain fatty acid catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0046322 [negative regulation of fatty acid oxidation]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0090181 [regulation of cholesterol metabolic process]
Show all
 678 aa
72.9 kDa 		No 0
ACADVL-015
ENSP00000465353
ENST00000584103
K7EJW8 [Direct mapping]
Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 158 aa
17.1 kDa 		No 0
ACADVL-024
ENSP00000442082
ENST00000542255
G3V1M7 [Direct mapping]
Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 282 aa
30.7 kDa 		No 0
ACADVL-037
ENSP00000467920
ENST00000583312
K7EQP4 [Direct mapping]
Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 225 aa
24 kDa 		No 0
ACADVL-040
ENSP00000463246
ENST00000579886
J3QKU9 [Direct mapping]
Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 155 aa
16.3 kDa 		No 0
ACADVL-041
ENSP00000464254
ENST00000579546
J3QRJ8 [Direct mapping]
Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 194 aa
21.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.