Fields »
ABOUT
HELP
BLOG
FBXW11

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 FBXW11

Gene description

 F-box and WD repeat domain containing 11

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli. In addition localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (approved)

Additional location

 In addition localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA062578
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli. In addition localized to vesicles.

Main location

 Nucleoli (approved)

Additional location

 Vesicles (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA062578 RH-30 Nucleoli
HPA062578 SiHa Nucleoli
Vesicles
HPA062578 U-2 OS Nucleoli

GENE INFORMATION

Gene name

 FBXW11 (HGNC Symbol)

Synonyms

 BTRC2, BTRCP2, Fbw11, Fbw1b, FBXW1B, Hos, KIAA0696

Description

 F-box and WD repeat domain containing 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.1

Chromosome location (bp)

 171861549 - 172006873

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072803 (version 83.38)

Entrez gene

 23291

UniProt

 Q9UKB1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKB1

Antibodypedia

 FBXW11 antibodies

PROTEIN BROWSER
FBXW11-001
FBXW11-002
FBXW11-003
FBXW11-007
FBXW11-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXW11-001
ENSP00000296933
ENST00000296933
Q9UKB1 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031648 [protein destabilization]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
Show all
 529 aa
60.9 kDa 		No 0
FBXW11-002
ENSP00000265094
ENST00000265094
Q9UKB1 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031648 [protein destabilization]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 542 aa
62.1 kDa 		No 0
FBXW11-003
ENSP00000377391
ENST00000393802
Q9UKB1 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031648 [protein destabilization]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
Show all
 508 aa
58.4 kDa 		No 0
FBXW11-007
ENSP00000428753
ENST00000517395
E5RGC1 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0046983 [protein dimerization activity]
Show all
 197 aa
22.7 kDa 		No 0
FBXW11-008
ENSP00000429818
ENST00000518752
E5RH92 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 74 aa
8.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.