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FBXW11

GENERAL INFORMATION

Gene name

 FBXW11

Gene description

 F-box and WD repeat domain containing 11

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA072204
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA072204

GENE INFORMATION

Gene name

 FBXW11 (HGNC Symbol)

Synonyms

 BTRC2, BTRCP2, Fbw11, Fbw1b, FBXW1B, Hos, KIAA0696

Description

 F-box and WD repeat domain containing 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.1

Chromosome location (bp)

 171861549 - 172006873

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072803 (version 83.38)

Entrez gene

 23291

UniProt

 Q9UKB1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKB1

Antibodypedia

 FBXW11 antibodies

PROTEIN BROWSER
FBXW11-001
FBXW11-002
FBXW11-003
FBXW11-007
FBXW11-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXW11-001
ENSP00000296933
ENST00000296933
Q9UKB1 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031648 [protein destabilization]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
Show all
 529 aa
60.9 kDa 		No 0
FBXW11-002
ENSP00000265094
ENST00000265094
Q9UKB1 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031648 [protein destabilization]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 542 aa
62.1 kDa 		No 0
FBXW11-003
ENSP00000377391
ENST00000393802
Q9UKB1 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031648 [protein destabilization]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
Show all
 508 aa
58.4 kDa 		No 0
FBXW11-007
ENSP00000428753
ENST00000517395
E5RGC1 [Direct mapping]
F-box/WD repeat-containing protein 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0046983 [protein dimerization activity]
Show all
 197 aa
22.7 kDa 		No 0
FBXW11-008
ENSP00000429818
ENST00000518752
E5RH92 [Direct mapping]
F-box/WD repeat-containing protein 11
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 74 aa
8.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.