Expression of DERL2 in cancer - Summary

GENERAL INFORMATION
Gene name	DERL2
Gene description	Derlin 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, high expression levels in exocrine pancreas, epididymis and a subset of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA048957 , HPA056551 , CAB037287
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048957	HPA056551	CAB037287

GENE INFORMATION
Gene name	DERL2 (HGNC Symbol)
Synonyms	CGI-101, derlin-2, F-LAN-1, F-LANa, FLANa
Description	Derlin 2 (HGNC Symbol)
Entrez gene summary	Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	5471251 - 5486811
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072849 (version 83.38)
Entrez gene	51009
UniProt	Q9GZP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZP9
Antibodypedia	DERL2 antibodies

PROTEIN BROWSER

DERL2-001	DERL2-008	DERL2-009	DERL2-010	DERL2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DERL2-001 ENSP00000158771 ENST00000158771	Q9GZP9 [Direct mapping] Derlin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001967 [suckling behavior] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030307 [positive regulation of cell growth] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	239 aa 27.6 kDa	No	5
DERL2-008 ENSP00000459072 ENST00000570848	I3L1S8 [Direct mapping] Derlin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	144 aa 17.2 kDa	No	4
DERL2-009 ENSP00000458296 ENST00000571971	I3L0R8 [Direct mapping] Derlin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	200 aa 23.4 kDa	No	6
DERL2-010 ENSP00000460671 ENST00000572834	I3L3R8 [Direct mapping] Derlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.8 kDa	No	0
DERL2-012 ENSP00000459083 ENST00000575605	I3L1T3 [Direct mapping] Derlin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	158 aa 18 kDa	No	3