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Method

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Cancer

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PICALM
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PICALM

Gene description

Phosphatidylinositol binding clathrin assembly protein

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

15
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and membranous expression, most abundant in gastrointestinal tract, kidney and placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA019053 , HPA019061
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 910111213141516 Renal cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all
0.020406080100120140160180FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA019053
HPA019061

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic staining was observed in most cancer tissues.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed moderate cytoplasmic staining. Several pancreatic cancers and a few liver cancers were strongly stained. Gliomas, melanomas and testicular cancers were weakly stained or negative.

GENE INFORMATION

Gene name

PICALM (HGNC Symbol)

Synonyms

CALM, CLTH

Description

Phosphatidylinositol binding clathrin assembly protein (HGNC Symbol)

Entrez gene summary

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

11

Cytoband

q14.2

Chromosome location (bp)

85957684 - 86069882

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000073921 (version 83.38)

Entrez gene

8301

UniProt

Q13492 (UniProt - Evidence at protein level)

neXtProt

NX_Q13492

Antibodypedia

PICALM antibodies

PROTEIN BROWSER

«
PICALM-001
PICALM-002
PICALM-003
PICALM-005
PICALM-006
PICALM-007
PICALM-008
PICALM-010
PICALM-017
PICALM-018
PICALM-019
PICALM-020
PICALM-021
PICALM-023
PICALM-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PICALM-001
ENSP00000433846
ENST00000526033
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
645 aa
70 kDa
No 0
PICALM-002
ENSP00000436958
ENST00000532317
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
A0A024R5L7 [Target identity:100%; Query identity:100%]
Phosphatidylinositol binding clathrin assembly protein, isoform CRA_c
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
610 aa
66.4 kDa
No 0
PICALM-003
ENSP00000434884
ENST00000528398
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
551 aa
59.9 kDa
No 0
PICALM-005
ENSP00000377015
ENST00000393346
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
A0A024R5P1 [Target identity:100%; Query identity:100%]
Phosphatidylinositol binding clathrin assembly protein, isoform CRA_i
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0007409 [axonogenesis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030097 [hemopoiesis]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048813 [dendrite morphogenesis]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
652 aa
70.8 kDa
No 0
PICALM-006
ENSP00000348718
ENST00000356360
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
632 aa
68.8 kDa
No 0
PICALM-007
ENSP00000433303
ENST00000531930
E9PLJ8 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0030276 [clathrin binding]
GO:0048268 [clathrin coat assembly]
Show all
185 aa
21.3 kDa
No 0
PICALM-008
ENSP00000436508
ENST00000525162
E9PI56 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0030276 [clathrin binding]
GO:0048268 [clathrin coat assembly]
Show all
148 aa
17 kDa
No 0
PICALM-010
ENSP00000431545
ENST00000528256
E9PKP6 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
148 aa
17.3 kDa
No 0
PICALM-017
ENSP00000435737
ENST00000530542
H0YEF7 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
302 aa
31.4 kDa
No 0
PICALM-018
ENSP00000435807
ENST00000529760
H0YEH1 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
308 aa
32.1 kDa
No 0
PICALM-019
ENSP00000432976
ENST00000526961
H0YD48 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
264 aa
27.7 kDa
No 0
PICALM-020
ENSP00000435311
ENST00000532603
H0YE97 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
134 aa
13.9 kDa
No 0
PICALM-021
ENSP00000436852
ENST00000530692
H0YEY8 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
215 aa
22.3 kDa
No 0
PICALM-023
ENSP00000432509
ENST00000529016
H0YCY1 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
244 aa
25.4 kDa
No 0
PICALM-201
ENSP00000487119
ENST00000630913
E9PK13 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
105 aa
11.6 kDa
No 0

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