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PICALM

GENERAL INFORMATION

Gene name

 PICALM

Gene description

 Phosphatidylinositol binding clathrin assembly protein

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and membranous expression, most abundant in gastrointestinal tract, kidney and placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA019053 , HPA019061
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019053
HPA019061

GENE INFORMATION

Gene name

 PICALM (HGNC Symbol)

Synonyms

 CALM, CLTH

Description

 Phosphatidylinositol binding clathrin assembly protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

 11

Cytoband

 q14.2

Chromosome location (bp)

 85957684 - 86069882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073921 (version 83.38)

Entrez gene

 8301

UniProt

 Q13492 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13492

Antibodypedia

 PICALM antibodies

PROTEIN BROWSER
«
PICALM-001
PICALM-002
PICALM-003
PICALM-005
PICALM-006
PICALM-007
PICALM-008
PICALM-010
PICALM-017
PICALM-018
PICALM-019
PICALM-020
PICALM-021
PICALM-023
PICALM-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PICALM-001
ENSP00000433846
ENST00000526033
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
 645 aa
70 kDa 		No 0
PICALM-002
ENSP00000436958
ENST00000532317
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
A0A024R5L7 [Target identity:100%; Query identity:100%]
Phosphatidylinositol binding clathrin assembly protein, isoform CRA_c
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
 610 aa
66.4 kDa 		No 0
PICALM-003
ENSP00000434884
ENST00000528398
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
 551 aa
59.9 kDa 		No 0
PICALM-005
ENSP00000377015
ENST00000393346
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
A0A024R5P1 [Target identity:100%; Query identity:100%]
Phosphatidylinositol binding clathrin assembly protein, isoform CRA_i
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0007409 [axonogenesis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030097 [hemopoiesis]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048813 [dendrite morphogenesis]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
 652 aa
70.8 kDa 		No 0
PICALM-006
ENSP00000348718
ENST00000356360
Q13492 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0005634 [nucleus]
GO:0005794 [Golgi apparatus]
GO:0005905 [coated pit]
GO:0006461 [protein complex assembly]
GO:0006898 [receptor-mediated endocytosis]
GO:0008283 [cell proliferation]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016188 [synaptic vesicle maturation]
GO:0016192 [vesicle-mediated transport]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030132 [clathrin coat of coated pit]
GO:0030276 [clathrin binding]
GO:0031623 [receptor internalization]
GO:0031982 [vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032880 [regulation of protein localization]
GO:0035459 [cargo loading into vesicle]
GO:0035615 [clathrin adaptor activity]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055072 [iron ion homeostasis]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097418 [neurofibrillary tangle]
GO:0097459 [iron ion import into cell]
GO:1901216 [positive regulation of neuron death]
GO:1902004 [positive regulation of beta-amyloid formation]
GO:1902959 [regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902961 [positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process]
GO:1902963 [negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process]
Show all
 632 aa
68.8 kDa 		No 0
PICALM-007
ENSP00000433303
ENST00000531930
E9PLJ8 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0030276 [clathrin binding]
GO:0048268 [clathrin coat assembly]
Show all
 185 aa
21.3 kDa 		No 0
PICALM-008
ENSP00000436508
ENST00000525162
E9PI56 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0030276 [clathrin binding]
GO:0048268 [clathrin coat assembly]
Show all
 148 aa
17 kDa 		No 0
PICALM-010
ENSP00000431545
ENST00000528256
E9PKP6 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
 148 aa
17.3 kDa 		No 0
PICALM-017
ENSP00000435737
ENST00000530542
H0YEF7 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
 302 aa
31.4 kDa 		No 0
PICALM-018
ENSP00000435807
ENST00000529760
H0YEH1 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
 308 aa
32.1 kDa 		No 0
PICALM-019
ENSP00000432976
ENST00000526961
H0YD48 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
 264 aa
27.7 kDa 		No 0
PICALM-020
ENSP00000435311
ENST00000532603
H0YE97 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
 134 aa
13.9 kDa 		No 0
PICALM-021
ENSP00000436852
ENST00000530692
H0YEY8 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
 215 aa
22.3 kDa 		No 0
PICALM-023
ENSP00000432509
ENST00000529016
H0YCY1 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
 244 aa
25.4 kDa 		No 0
PICALM-201
ENSP00000487119
ENST00000630913
E9PK13 [Direct mapping]
Phosphatidylinositol-binding clathrin assembly protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005545 [1-phosphatidylinositol binding]
GO:0006897 [endocytosis]
GO:0030136 [clathrin-coated vesicle]
GO:0048268 [clathrin coat assembly]
Show all
 105 aa
11.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.