Tissue expression of CDHR2 - Summary - The Human Protein Atlas

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CDHR2

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CDHR2
Gene description	Cadherin-related family member 2
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (duodenum, small intestine)
GTEx:	Tissue enriched (small intestine)
FANTOM5:	Group enriched (colon, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Expression in luminal membranes of renal tubules and the intestinal tract.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA012569 , HPA017053
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (duodenum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, small intestine)

GENE INFORMATION
Gene name	CDHR2 (HGNC Symbol)
Synonyms	FLJ20124, FLJ20383, PC-LKC, PCDH24, PCLKC
Description	Cadherin-related family member 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jan 2010]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	176542511 - 176595974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074276 (version 83.38)
Entrez gene	54825
UniProt	Q9BYE9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYE9
Antibodypedia	CDHR2 antibodies

PROTEIN BROWSER

CDHR2-001	CDHR2-002	CDHR2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDHR2-001 ENSP00000424565 ENST00000510636	Q9BYE9 [Direct mapping] Cadherin-related family member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005903 [brush border] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030054 [cell junction] GO:0030308 [negative regulation of cell growth] GO:0070062 [extracellular exosome] Show all	1310 aa 141.5 kDa	Yes	1
CDHR2-002 ENSP00000421078 ENST00000506348	Q9BYE9 [Direct mapping] Cadherin-related family member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005903 [brush border] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030054 [cell junction] GO:0030308 [negative regulation of cell growth] GO:0070062 [extracellular exosome] Show all	1310 aa 141.5 kDa	Yes	1
CDHR2-003 ENSP00000261944 ENST00000261944	Q9BYE9 [Direct mapping] Cadherin-related family member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005903 [brush border] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030054 [cell junction] GO:0030308 [negative regulation of cell growth] GO:0070062 [extracellular exosome] Show all	1310 aa 141.5 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.