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FOSL2

GENERAL INFORMATION

Gene name

 FOSL2

Gene description

 FOS-like antigen 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA004817 , HPA061417 , CAB013460
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA004817
HPA061417
CAB013460

GENE INFORMATION

Gene name

 FOSL2 (HGNC Symbol)

Synonyms

 FLJ23306, FRA2

Description

 FOS-like antigen 2 (HGNC Symbol)

Entrez gene summary

 The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

Chromosome

 2

Cytoband

 p23.2

Chromosome location (bp)

 28392448 - 28417312

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075426 (version 83.38)

Entrez gene

 2355

UniProt

 P15408 (UniProt - Evidence at protein level)

neXtProt

 NX_P15408

Antibodypedia

 FOSL2 antibodies

PROTEIN BROWSER
FOSL2-001
FOSL2-002
FOSL2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOSL2-001
ENSP00000264716
ENST00000264716
P15408 [Direct mapping]
Fos-related antigen 2
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003334 [keratinocyte development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008219 [cell death]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048146 [positive regulation of fibroblast proliferation]
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 326 aa
35.2 kDa 		No 0
FOSL2-002
ENSP00000368939
ENST00000379619
P15408 [Direct mapping]
Fos-related antigen 2
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008219 [cell death]
GO:0043565 [sequence-specific DNA binding]
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 318 aa
34.8 kDa 		No 0
FOSL2-004
ENSP00000396497
ENST00000436647
C9JCN8 [Direct mapping]
Fos-related antigen 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
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 202 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.