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RAB7A

GENERAL INFORMATION

Gene name

 RAB7A

Gene description

 RAB7A, member RAS oncogene family

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006964 , CAB037131
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable) and pancreatic cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006964
CAB037131

GENE INFORMATION

Gene name

 RAB7A (HGNC Symbol)

Synonyms

 RAB7

Description

 RAB7A, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 128726122 - 128814796

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075785 (version 83.38)

Entrez gene

 7879

UniProt

 P51149 (UniProt - Evidence at protein level)

neXtProt

 NX_P51149

Antibodypedia

 RAB7A antibodies

PROTEIN BROWSER
RAB7A-001
RAB7A-004
RAB7A-006
RAB7A-009
RAB7A-010
RAB7A-011
RAB7A-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB7A-001
ENSP00000265062
ENST00000265062
P51149 [Direct mapping]
Ras-related protein Rab-7a
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000421 [autophagosome membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005770 [late endosome]
GO:0005774 [vacuolar membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid particle]
GO:0006622 [protein targeting to lysosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007174 [epidermal growth factor catabolic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008333 [endosome to lysosome transport]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0019076 [viral release from host cell]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0022615 [protein to membrane docking]
GO:0030670 [phagocytic vesicle membrane]
GO:0030904 [retromer complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031902 [late endosome membrane]
GO:0032419 [extrinsic component of lysosome membrane]
GO:0032482 [Rab protein signal transduction]
GO:0033162 [melanosome membrane]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043195 [terminal bouton]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045022 [early endosome to late endosome transport]
GO:0045335 [phagocytic vesicle]
GO:0045453 [bone resorption]
GO:0045732 [positive regulation of protein catabolic process]
GO:0048365 [Rac GTPase binding]
GO:0048524 [positive regulation of viral process]
GO:0061724 [lipophagy]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
GO:0090383 [phagosome acidification]
GO:0090385 [phagosome-lysosome fusion]
GO:0097208 [alveolar lamellar body]
GO:1903543 [positive regulation of exosomal secretion]
GO:2000785 [regulation of autophagosome assembly]
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 207 aa
23.5 kDa 		No 0
RAB7A-004
ENSP00000417668
ENST00000482525
C9J8S3 [Direct mapping]
Ras-related protein Rab-7a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005774 [vacuolar membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
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 160 aa
18 kDa 		No 0
RAB7A-006
ENSP00000417978
ENST00000464496
C9J592 [Direct mapping]
Ras-related protein Rab-7a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005774 [vacuolar membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
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 150 aa
17 kDa 		No 0
RAB7A-009
ENSP00000418955
ENST00000490093
C9IZZ0 [Direct mapping]
Ras-related protein Rab-7a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005774 [vacuolar membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
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 116 aa
13.1 kDa 		No 0
RAB7A-010
ENSP00000417189
ENST00000493186
C9J4S4 [Direct mapping]
Ras-related protein Rab-7a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005774 [vacuolar membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0032482 [Rab protein signal transduction]
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 98 aa
11 kDa 		No 0
RAB7A-011
ENSP00000417155
ENST00000483906
C9J4V0 [Direct mapping]
Ras-related protein Rab-7a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005774 [vacuolar membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
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 134 aa
15.1 kDa 		No 0
RAB7A-012
ENSP00000418283
ENST00000485280
C9J7D1 [Direct mapping]
Ras-related protein Rab-7a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005774 [vacuolar membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0032482 [Rab protein signal transduction]
Show all
 91 aa
10.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.