Expression of MKRN2 in cancer - Summary

GENERAL INFORMATION
Gene name	MKRN2
Gene description	Makorin ring finger protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with additional nuclear expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA037559 , HPA037560
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA037559	HPA037560

GENE INFORMATION
Gene name	MKRN2 (HGNC Symbol)
Synonyms	HSPC070, RNF62
Description	Makorin ring finger protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	3
Cytoband	p25.2
Chromosome location (bp)	12557014 - 12583713
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075975 (version 83.38)
Entrez gene	23609
UniProt	Q9H000 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H000
Antibodypedia	MKRN2 antibodies

PROTEIN BROWSER

MKRN2-001	MKRN2-002	MKRN2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKRN2-001 ENSP00000170447 ENST00000170447	Q9H000 [Direct mapping] Probable E3 ubiquitin-protein ligase makorin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	416 aa 46.9 kDa	No	0
MKRN2-002 ENSP00000396340 ENST00000411987	Q9H000 [Direct mapping] Probable E3 ubiquitin-protein ligase makorin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	373 aa 42 kDa	No	0
MKRN2-003 ENSP00000397983 ENST00000448482	C9J494 [Direct mapping] Probable E3 ubiquitin-protein ligase makorin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	414 aa 46.7 kDa	No	0