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MKRN2

GENERAL INFORMATION

Gene name

 MKRN2

Gene description

 Makorin ring finger protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with additional nuclear expression in a few tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA037559 , HPA037560
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MKRN2 (HGNC Symbol)

Synonyms

 HSPC070, RNF62

Description

 Makorin ring finger protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

 3

Cytoband

 p25.2

Chromosome location (bp)

 12557014 - 12583713

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075975 (version 83.38)

Entrez gene

 23609

UniProt

 Q9H000 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H000

Antibodypedia

 MKRN2 antibodies

PROTEIN BROWSER
MKRN2-001
MKRN2-002
MKRN2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MKRN2-001
ENSP00000170447
ENST00000170447
Q9H000 [Direct mapping]
Probable E3 ubiquitin-protein ligase makorin-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 416 aa
46.9 kDa 		No 0
MKRN2-002
ENSP00000396340
ENST00000411987
Q9H000 [Direct mapping]
Probable E3 ubiquitin-protein ligase makorin-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008150 [biological_process]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
 373 aa
42 kDa 		No 0
MKRN2-003
ENSP00000397983
ENST00000448482
C9J494 [Direct mapping]
Probable E3 ubiquitin-protein ligase makorin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 414 aa
46.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.