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TPD52

GENERAL INFORMATION

Gene name

 TPD52

Gene description

 Tumor protein D52

Protein class

 Cancer-related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SK-BR-3)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA028427 , HPA062167
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA028427
HPA062167

GENE INFORMATION

Gene name

 TPD52 (HGNC Symbol)

Synonyms

 D52, hD52, N8L

Description

 Tumor protein D52 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q21.13

Chromosome location (bp)

 80034745 - 80231232

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076554 (version 83.38)

Entrez gene

 7163

UniProt

 P55327 (UniProt - Evidence at protein level)

neXtProt

 NX_P55327

Antibodypedia

 TPD52 antibodies

PROTEIN BROWSER
TPD52-001
TPD52-002
TPD52-003
TPD52-005
TPD52-006
TPD52-008
TPD52-012
TPD52-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPD52-001
ENSP00000429915
ENST00000518937
P55327 [Direct mapping]
Tumor protein D52
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0009653 [anatomical structure morphogenesis]
GO:0030183 [B cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0046903 [secretion]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
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 207 aa
22.5 kDa 		No 0
TPD52-002
ENSP00000368390
ENST00000379096
P55327 [Direct mapping]
Tumor protein D52
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0009653 [anatomical structure morphogenesis]
GO:0030183 [B cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0046903 [secretion]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 184 aa
19.9 kDa 		No 0
TPD52-003
ENSP00000428951
ENST00000519303
E5RK35 [Direct mapping]
Tumor protein D52
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 60 aa
6.3 kDa 		No 0
TPD52-005
ENSP00000429309
ENST00000520527
P55327 [Direct mapping]
Tumor protein D52
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0009653 [anatomical structure morphogenesis]
GO:0030183 [B cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0046903 [secretion]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 247 aa
26.9 kDa 		No 0
TPD52-006
ENSP00000368391
ENST00000379097
P55327 [Direct mapping]
Tumor protein D52
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0009653 [anatomical structure morphogenesis]
GO:0030183 [B cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0046903 [secretion]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 224 aa
24.3 kDa 		No 0
TPD52-008
ENSP00000429351
ENST00000517427
P55327 [Direct mapping]
Tumor protein D52
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0009653 [anatomical structure morphogenesis]
GO:0030183 [B cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0046903 [secretion]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 233 aa
25.4 kDa 		No 0
TPD52-012
ENSP00000430865
ENST00000520795
H0YC44 [Direct mapping]
Tumor protein D52
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 148 aa
16 kDa 		Yes 0
TPD52-201
ENSP00000410222
ENST00000448733
P55327 [Direct mapping]
Tumor protein D52
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0009653 [anatomical structure morphogenesis]
GO:0030183 [B cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0046903 [secretion]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 238 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.