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RAP1GAP

GENERAL INFORMATION

Gene name

 RAP1GAP

Gene description

 RAP1 GTPase activating protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, SCLC-21H)
HPA (normal tissue):Tissue enhanced (cerebral cortex, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues. Highly expressed in the CNS, kidney, thyroid gland and exocrine pancreas.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA001922
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA001922

GENE INFORMATION

Gene name

 RAP1GAP (HGNC Symbol)

Synonyms

 KIAA0474, RAP1GA1, RAP1GAP1, RAP1GAPII

Description

 RAP1 GTPase activating protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 21596215 - 21669363

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076864 (version 83.38)

Entrez gene

 5909

UniProt

 P47736 (UniProt - Evidence at protein level)

neXtProt

 NX_P47736

Antibodypedia

 RAP1GAP antibodies

PROTEIN BROWSER
RAP1GAP-001
RAP1GAP-004
RAP1GAP-005
RAP1GAP-009
RAP1GAP-011
RAP1GAP-014
RAP1GAP-015
RAP1GAP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAP1GAP-001
ENSP00000363897
ENST00000374765
P47736 [Direct mapping]
Rap1 GTPase-activating protein 1
A0A024RAB5 [Target identity:100%; Query identity:100%]
RAP1, GTPase activating protein 1, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0017016 [Ras GTPase binding]
GO:0030695 [GTPase regulator activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:1903697 [negative regulation of microvillus assembly]
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 663 aa
73.4 kDa 		No 0
RAP1GAP-004
ENSP00000363893
ENST00000374761
J3KPC5 [Direct mapping]
RAP1, GTPase activating protein 1, isoform CRA_e; Rap1 GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0030695 [GTPase regulator activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
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 694 aa
76.7 kDa 		No 0
RAP1GAP-005
ENSP00000315420
ENST00000317967
Q5T3T1 [Direct mapping]
Rap1 GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0030695 [GTPase regulator activity]
GO:0050790 [regulation of catalytic activity]
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 96 aa
11 kDa 		No 0
RAP1GAP-009
ENSP00000392717
ENST00000447293
Q5T3T0 [Direct mapping]
Rap1 GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0030695 [GTPase regulator activity]
GO:0050790 [regulation of catalytic activity]
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 36 aa
4.3 kDa 		No 0
RAP1GAP-011
ENSP00000434033
ENST00000495204
P47736 [Direct mapping]
Rap1 GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0017016 [Ras GTPase binding]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030695 [GTPase regulator activity]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045665 [negative regulation of neuron differentiation]
GO:0050766 [positive regulation of phagocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:1903697 [negative regulation of microvillus assembly]
GO:1904425 [negative regulation of GTP binding]
GO:1904442 [negative regulation of thyroid gland epithelial cell proliferation]
GO:1990792 [cellular response to glial cell derived neurotrophic factor]
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 727 aa
80.6 kDa 		No 0
RAP1GAP-014
ENSP00000441661
ENST00000542643
P47736 [Direct mapping]
Rap1 GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0017016 [Ras GTPase binding]
GO:0030695 [GTPase regulator activity]
GO:0042803 [protein homodimerization activity]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:1903697 [negative regulation of microvillus assembly]
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 681 aa
75.2 kDa 		No 0
RAP1GAP-015
ENSP00000363895
ENST00000374763
X6R8W7 [Direct mapping]
Rap1 GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0030695 [GTPase regulator activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 748 aa
81.7 kDa 		No 0
RAP1GAP-201
ENSP00000290101
ENST00000290101
A0A0A0MQY8 [Direct mapping]
Rap1 GTPase-activating protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0030695 [GTPase regulator activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 692 aa
76.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.