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ARHGEF1

GENERAL INFORMATION

Gene name

 ARHGEF1

Gene description

 Rho guanine nucleotide exchange factor (GEF) 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA012924 , CAB009502
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012924
CAB009502

GENE INFORMATION

Gene name

 ARHGEF1 (HGNC Symbol)

Synonyms

 LBCL2, P115-RHOGEF, SUB1.5

Description

 Rho guanine nucleotide exchange factor (GEF) 1 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 41883161 - 41930150

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000076928 (version 83.38)

Entrez gene

 9138

UniProt

 Q92888 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92888

Antibodypedia

 ARHGEF1 antibodies

PROTEIN BROWSER
ARHGEF1-001
ARHGEF1-005
ARHGEF1-006
ARHGEF1-007
ARHGEF1-009
ARHGEF1-010
ARHGEF1-015
ARHGEF1-017
ARHGEF1-022
ARHGEF1-024

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF1-001
ENSP00000344429
ENST00000347545
Q92888 [Direct mapping]
Rho guanine nucleotide exchange factor 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008283 [cell proliferation]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
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 879 aa
98.8 kDa 		No 0
ARHGEF1-005
ENSP00000346532
ENST00000354532
Q92888 [Direct mapping]
Rho guanine nucleotide exchange factor 1
A0A024R0R1 [Target identity:100%; Query identity:100%]
Rho guanine nucleotide exchange factor (GEF) 1, isoform CRA_e
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008283 [cell proliferation]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
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 912 aa
102.4 kDa 		No 0
ARHGEF1-006
ENSP00000337261
ENST00000337665
Q92888 [Direct mapping]
Rho guanine nucleotide exchange factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008283 [cell proliferation]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
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 927 aa
104.1 kDa 		No 0
ARHGEF1-007
ENSP00000367394
ENST00000378152
Q92888 [Direct mapping]
Rho guanine nucleotide exchange factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007266 [Rho protein signal transduction]
GO:0008283 [cell proliferation]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
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 948 aa
105.9 kDa 		No 0
ARHGEF1-009
ENSP00000469735
ENST00000599589
M0QYC1 [Direct mapping]
Rho guanine nucleotide exchange factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 702 aa
78.5 kDa 		No 0
ARHGEF1-010
ENSP00000470715
ENST00000599846
M0QZR4 [Direct mapping]
Rho guanine nucleotide exchange factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 968 aa
108.3 kDa 		No 0
ARHGEF1-015
ENSP00000470557
ENST00000594521
M0QZH8 [Direct mapping]
Rho guanine nucleotide exchange factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 275 aa
30 kDa 		No 0
ARHGEF1-017
ENSP00000470042
ENST00000594258
M0QYS3 [Direct mapping]
Rho guanine nucleotide exchange factor 1
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   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 307 aa
34.2 kDa 		No 0
ARHGEF1-022
ENSP00000472466
ENST00000595723
M0R2C7 [Direct mapping]
Rho guanine nucleotide exchange factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 291 aa
32.8 kDa 		No 0
ARHGEF1-024
ENSP00000471942
ENST00000594417
M0R1K8 [Direct mapping]
Rho guanine nucleotide exchange factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 128 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.