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ACTL6B

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GENERAL INFORMATION

Gene name

 ACTL6B

Gene description

 Actin-like 6B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli.

RNA cell category

 Group enriched (SCLC-21H, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA045126
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli.

Main location

 Nucleoli (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA045126 A-431 Nucleoli
HPA045126 U-2 OS Nucleoli
HPA045126 U-251 MG Nucleoli

GENE INFORMATION

Gene name

 ACTL6B (HGNC Symbol)

Synonyms

 ACTL6, BAF53B

Description

 Actin-like 6B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100643097 - 100656461

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077080 (version 83.38)

Entrez gene

 51412

UniProt

 O94805 (UniProt - Evidence at protein level)

neXtProt

 NX_O94805

Antibodypedia

 ACTL6B antibodies

PROTEIN BROWSER
ACTL6B-001
ACTL6B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTL6B-001
ENSP00000160382
ENST00000160382
O94805 [Direct mapping]
Actin-like protein 6B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003713 [transcription coactivator activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0016514 [SWI/SNF complex]
GO:0021510 [spinal cord development]
GO:0070603 [SWI/SNF superfamily-type complex]
GO:0071565 [nBAF complex]
GO:0090544 [BAF-type complex]
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 426 aa
46.9 kDa 		No 0
ACTL6B-002
ENSP00000420151
ENST00000461605
C9JQT4 [Direct mapping]
Actin-like protein 6B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 66 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.