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ACTL6B

GENERAL INFORMATION

Gene name

 ACTL6B

Gene description

 Actin-like 6B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, pancreatic cancer)
HPA (cell line):Group enriched (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results.

Reliability score

 Uncertain based on 1 antibody.
HPA045126
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045126

GENE INFORMATION

Gene name

 ACTL6B (HGNC Symbol)

Synonyms

 ACTL6, BAF53B

Description

 Actin-like 6B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100643097 - 100656461

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077080 (version 83.38)

Entrez gene

 51412

UniProt

 O94805 (UniProt - Evidence at protein level)

neXtProt

 NX_O94805

Antibodypedia

 ACTL6B antibodies

PROTEIN BROWSER
ACTL6B-001
ACTL6B-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTL6B-001
ENSP00000160382
ENST00000160382
O94805 [Direct mapping]
Actin-like protein 6B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003713 [transcription coactivator activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0016514 [SWI/SNF complex]
GO:0021510 [spinal cord development]
GO:0070603 [SWI/SNF superfamily-type complex]
GO:0071565 [nBAF complex]
GO:0090544 [BAF-type complex]
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 426 aa
46.9 kDa 		No 0
ACTL6B-002
ENSP00000420151
ENST00000461605
C9JQT4 [Direct mapping]
Actin-like protein 6B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 66 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.