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NFKB2

GENERAL INFORMATION

Gene name

 NFKB2

Gene description

 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, highest expression in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein profile.

Reliability score

 Supported based on 3 antibodies.
HPA008422 , HPA023900 , CAB022098
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), melanoma (favourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001
Melanoma p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA008422
HPA023900
CAB022098

GENE INFORMATION

Gene name

 NFKB2 (HGNC Symbol)

Synonyms

 LYT-10, NF-kB2, p105, p52

Description

 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 102394110 - 102402529

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077150 (version 83.38)

Entrez gene

 4791

UniProt

 Q00653 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00653

Antibodypedia

 NFKB2 antibodies

PROTEIN BROWSER
NFKB2-001
NFKB2-003
NFKB2-004
NFKB2-007
NFKB2-201
NFKB2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFKB2-001
ENSP00000189444
ENST00000189444
Q00653 [Direct mapping]
Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p52 subunit
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0033257 [Bcl3/NF-kappaB2 complex]
GO:0034097 [response to cytokine]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 899 aa
96.7 kDa 		No 0
NFKB2-003
ENSP00000358983
ENST00000369966
Q00653 [Direct mapping]
Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p52 subunit
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002268 [follicular dendritic cell differentiation]
GO:0002467 [germinal center formation]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007568 [aging]
GO:0030198 [extracellular matrix organization]
GO:0032481 [positive regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0033257 [Bcl3/NF-kappaB2 complex]
GO:0034097 [response to cytokine]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:0048536 [spleen development]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 900 aa
96.7 kDa 		No 0
NFKB2-004
ENSP00000471586
ENST00000471698
M0R119 [Direct mapping]
Nuclear factor NF-kappa-B p100 subunit
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0034097 [response to cytokine]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0045087 [innate immune response]
Show all
 68 aa
7.4 kDa 		No 0
NFKB2-007
ENSP00000470826
ENST00000601386
M0QZX1 [Direct mapping]
Nuclear factor NF-kappa-B p100 subunit
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003682 [chromatin binding]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0034097 [response to cytokine]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0045087 [innate immune response]
Show all
 22 aa
2.5 kDa 		No 0
NFKB2-201
ENSP00000410256
ENST00000428099
Q00653 [Direct mapping]
Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p52 subunit
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0033257 [Bcl3/NF-kappaB2 complex]
GO:0034097 [response to cytokine]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048511 [rhythmic process]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 899 aa
96.7 kDa 		No 0
NFKB2-202
ENSP00000480211
ENST00000610498
A0A087WWG7 [Direct mapping]
Nuclear factor NF-kappa-B p100 subunit
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0034097 [response to cytokine]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0045087 [innate immune response]
Show all
 415 aa
45.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.