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PAK3

GENERAL INFORMATION

Gene name

 PAK3

Gene description

 P21 protein (Cdc42/Rac)-activated kinase 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (hypothalamus, pituitary gland)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression restricted to Purkinje cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA060219
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PAK3 (HGNC Symbol)

Synonyms

 bPAK, hPAK3, MRX30, MRX47

Description

 P21 protein (Cdc42/Rac)-activated kinase 3 (HGNC Symbol)

Entrez gene summary

 PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q23

Chromosome location (bp)

 110944285 - 111227361

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077264 (version 83.38)

Entrez gene

 5063

UniProt

 O75914 (UniProt - Evidence at protein level)

neXtProt

 NX_O75914

Antibodypedia

 PAK3 antibodies

PROTEIN BROWSER
«
PAK3-001
PAK3-002
PAK3-003
PAK3-006
PAK3-007
PAK3-201
PAK3-202
PAK3-203
PAK3-204
PAK3-205
PAK3-206
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAK3-001
ENSP00000361077
ENST00000372007
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
Show all
 544 aa
60.7 kDa 		No 0
PAK3-002
ENSP00000361080
ENST00000372010
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
Show all
 559 aa
62.3 kDa 		No 0
PAK3-003
ENSP00000405642
ENST00000429193
B1AKS5 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 181 aa
20.2 kDa 		No 0
PAK3-006
ENSP00000429113
ENST00000519681
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
Show all
 565 aa
62.9 kDa 		No 0
PAK3-007
ENSP00000428921
ENST00000518291
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
Show all
 580 aa
64.5 kDa 		No 0
PAK3-201
ENSP00000262836
ENST00000262836
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
Show all
 559 aa
62.3 kDa 		No 0
PAK3-202
ENSP00000353864
ENST00000360648
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0010975 [regulation of neuron projection development]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017048 [Rho GTPase binding]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0051020 [GTPase binding]
GO:0060996 [dendritic spine development]
GO:0060997 [dendritic spine morphogenesis]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0071407 [cellular response to organic cyclic compound]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 580 aa
64.5 kDa 		No 0
PAK3-203
ENSP00000389172
ENST00000417227
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
Show all
 565 aa
62.9 kDa 		No 0
PAK3-204
ENSP00000401982
ENST00000425146
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
Show all
 544 aa
60.7 kDa 		No 0
PAK3-205
ENSP00000410853
ENST00000446737
O75914 [Direct mapping]
Serine/threonine-protein kinase PAK 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0016358 [dendrite development]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031295 [T cell costimulation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0050808 [synapse organization]
GO:0050852 [T cell receptor signaling pathway]
GO:0060997 [dendritic spine morphogenesis]
Show all
 544 aa
60.7 kDa 		No 0
PAK3-206
ENSP00000484798
ENST00000620137
A0A087X294 [Direct mapping]
Non-specific serine/threonine protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0048365 [Rac GTPase binding]
Show all
 543 aa
60.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.