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EXOSC5

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GENERAL INFORMATION

Gene name

 EXOSC5

Gene description

 Exosome component 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli. In addition localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (validated)

Additional location

 In addition localized to the Nucleus (uncertain)

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA055677
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ASSAYS
RNA expression
Human cells
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli. In addition localized to the nucleus.

Main location

 Nucleoli (validated)

Additional location

 Nucleus (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA055677 CACO-2 Nucleus
Nucleoli
HPA055677 MCF7 Nucleus
Nucleoli
HPA055677 U-2 OS Nucleus
Nucleoli

GFP

Antibody

 HPA055677

Validation

C-terminal tag
BAC cell line: 5898
Validated: Antibody staining overlaps with GFP tagged protein but show additional locations

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA055677 HeLa 5898 C-terminal Nucleus, Nucleoli Nucleoli
HPA055677 HeLa Normal - Nucleus, Nucleoli -

GENE INFORMATION

Gene name

 EXOSC5 (HGNC Symbol)

Synonyms

 hRrp46p, MGC12901, p12B, RRP41B, RRP46, Rrp46p

Description

 Exosome component 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 41386374 - 41397479

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077348 (version 83.38)

Entrez gene

 56915

UniProt

 Q9NQT4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQT4

Antibodypedia

 EXOSC5 antibodies

PROTEIN BROWSER
EXOSC5-001
EXOSC5-003
EXOSC5-004
EXOSC5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOSC5-001
ENSP00000221233
ENST00000221233
Q9NQT4 [Direct mapping]
Exosome complex component RRP46
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0010467 [gene expression]
GO:0016075 [rRNA catabolic process]
GO:0031125 [rRNA 3'-end processing]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0035327 [transcriptionally active chromatin]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0045006 [DNA deamination]
GO:0051607 [defense response to virus]
GO:0071028 [nuclear mRNA surveillance]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 235 aa
25.2 kDa 		No 0
EXOSC5-003
ENSP00000472396
ENST00000602129
M0R289 [Direct mapping]
Exosome complex component RRP46
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0016075 [rRNA catabolic process]
GO:0031125 [rRNA 3'-end processing]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0071028 [nuclear mRNA surveillance]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
Show all
 62 aa
6.5 kDa 		No 0
EXOSC5-004
ENSP00000471557
ENST00000593771
M0R102 [Direct mapping]
Exosome complex component RRP46
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0016075 [rRNA catabolic process]
GO:0031125 [rRNA 3'-end processing]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0071028 [nuclear mRNA surveillance]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
Show all
 134 aa
14.2 kDa 		No 0
EXOSC5-005
ENSP00000471002
ENST00000596905
M0R050 [Direct mapping]
Exosome complex component RRP46
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0016075 [rRNA catabolic process]
GO:0031125 [rRNA 3'-end processing]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0071028 [nuclear mRNA surveillance]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
Show all
 197 aa
21.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.