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RNA cell line category: Cell line enhanced (HEK 293, WM-115, SH-SY5Y, BJ hTERT+ SV40 Large T+ RasG12V, RH-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
ACTN2
Synonyms
Description
Actinin, alpha 2 (HGNC Symbol)
Entrez gene summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0002576 [platelet degranulation] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0008286 [insulin receptor signaling pathway] GO:0008307 [structural constituent of muscle] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019904 [protein domain specific binding] GO:0030018 [Z disc] GO:0030035 [microspike assembly] GO:0030049 [muscle filament sliding] GO:0030168 [platelet activation] GO:0030175 [filopodium] GO:0031093 [platelet alpha granule lumen] GO:0031143 [pseudopodium] GO:0031432 [titin binding] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042391 [regulation of membrane potential] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043197 [dendritic spine] GO:0043267 [negative regulation of potassium ion transport] GO:0043268 [positive regulation of potassium ion transport] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045214 [sarcomere organization] GO:0046983 [protein dimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048041 [focal adhesion assembly] GO:0051289 [protein homotetramerization] GO:0051373 [FATZ binding] GO:0051695 [actin filament uncapping] GO:0070062 [extracellular exosome] GO:0070080 [titin Z domain binding] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:0090002 [establishment of protein localization to plasma membrane] GO:1901017 [negative regulation of potassium ion transmembrane transporter activity] GO:1901018 [positive regulation of potassium ion transmembrane transporter activity] GO:2000009 [negative regulation of protein localization to cell surface] GO:2001137 [positive regulation of endocytic recycling] GO:2001259 [positive regulation of cation channel activity]