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UBE2A

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GENERAL INFORMATION

Gene name

 UBE2A

Gene description

 Ubiquitin-conjugating enzyme E2A

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the cytosol & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Plasma membrane (supported)

Additional location

 In addition localized to the Vesicles (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 3 antibodies.
HPA003875 , HPA051765 , HPA065898
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the cytosol & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleoplasm (supported), Plasma membrane (supported)

Additional location

 Vesicles (supported), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA003875 A549 Nucleoplasm
Cytosol
HPA003875 PC-3 Nucleoplasm
Plasma membrane
HPA003875 U-2 OS Nucleoplasm
Cytosol
HPA051765 A-431 Nucleoplasm
Vesicles
HPA051765 U-2 OS Nucleoplasm
Vesicles
HPA051765 U-251 MG Nucleoplasm
Vesicles
Plasma membrane
HPA065898 A-431 Nucleus
Plasma membrane
HPA065898 SK-MEL-30 Nucleoplasm
HPA065898 U-2 OS Nucleus

GENE INFORMATION

Gene name

 UBE2A (HGNC Symbol)

Synonyms

 HHR6A, RAD6A, UBC2

Description

 Ubiquitin-conjugating enzyme E2A (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 q24

Chromosome location (bp)

 119574467 - 119591083

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077721 (version 83.38)

Entrez gene

 7319

UniProt

 P49459 (UniProt - Evidence at protein level)

neXtProt

 NX_P49459

Antibodypedia

 UBE2A antibodies

PROTEIN BROWSER
UBE2A-001
UBE2A-002
UBE2A-006
UBE2A-007
UBE2A-009
UBE2A-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2A-001
ENSP00000360613
ENST00000371558
P49459 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0001701 [in utero embryonic development]
GO:0001741 [XY body]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006301 [postreplication repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033503 [HULC complex]
GO:0033522 [histone H2A ubiquitination]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051865 [protein autoubiquitination]
GO:0060135 [maternal process involved in female pregnancy]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 152 aa
17.3 kDa 		No 0
UBE2A-002
ENSP00000486599
ENST00000625938
P49459 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006301 [postreplication repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033503 [HULC complex]
GO:0033522 [histone H2A ubiquitination]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 122 aa
13.8 kDa 		No 0
UBE2A-006
ENSP00000335027
ENST00000346330
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 149 aa
17 kDa 		No 0
UBE2A-007
ENSP00000486153
ENST00000631185
A0A0D9SEZ6 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 123 aa
14 kDa 		No 0
UBE2A-009
ENSP00000487203
ENST00000628549
A0A0D9SG71 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 119 aa
13.6 kDa 		No 0
UBE2A-010
ENSP00000486550
ENST00000630695
P49459 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006301 [postreplication repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033503 [HULC complex]
GO:0033522 [histone H2A ubiquitination]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 77 aa
8.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.