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UBE2A

GENERAL INFORMATION

Gene name

 UBE2A

Gene description

 Ubiquitin-conjugating enzyme E2A

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBE2A (HGNC Symbol)

Synonyms

 HHR6A, RAD6A, UBC2

Description

 Ubiquitin-conjugating enzyme E2A (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 q24

Chromosome location (bp)

 119574467 - 119591083

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077721 (version 83.38)

Entrez gene

 7319

UniProt

 P49459 (UniProt - Evidence at protein level)

neXtProt

 NX_P49459

Antibodypedia

 UBE2A antibodies

PROTEIN BROWSER
UBE2A-001
UBE2A-002
UBE2A-006
UBE2A-007
UBE2A-009
UBE2A-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2A-001
ENSP00000360613
ENST00000371558
P49459 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0001701 [in utero embryonic development]
GO:0001741 [XY body]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006301 [postreplication repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033503 [HULC complex]
GO:0033522 [histone H2A ubiquitination]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051865 [protein autoubiquitination]
GO:0060135 [maternal process involved in female pregnancy]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 152 aa
17.3 kDa 		No 0
UBE2A-002
ENSP00000486599
ENST00000625938
P49459 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006301 [postreplication repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033503 [HULC complex]
GO:0033522 [histone H2A ubiquitination]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 122 aa
13.8 kDa 		No 0
UBE2A-006
ENSP00000335027
ENST00000346330
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 149 aa
17 kDa 		No 0
UBE2A-007
ENSP00000486153
ENST00000631185
A0A0D9SEZ6 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 123 aa
14 kDa 		No 0
UBE2A-009
ENSP00000487203
ENST00000628549
A0A0D9SG71 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 119 aa
13.6 kDa 		No 0
UBE2A-010
ENSP00000486550
ENST00000630695
P49459 [Direct mapping]
Ubiquitin-conjugating enzyme E2 A
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006301 [postreplication repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0009411 [response to UV]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033503 [HULC complex]
GO:0033522 [histone H2A ubiquitination]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 77 aa
8.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.