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MAP2

GENERAL INFORMATION

Gene name

 MAP2

Gene description

 Microtubule-associated protein 2

Protein class

 FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in neuronal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA008273 , HPA012828 , CAB001984
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA008273
HPA012828
CAB001984

GENE INFORMATION

Gene name

 MAP2 (HGNC Symbol)

Synonyms

 MAP2A, MAP2B, MAP2C

Description

 Microtubule-associated protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

Chromosome

 2

Cytoband

 q34

Chromosome location (bp)

 209424058 - 209734118

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078018 (version 83.38)

Entrez gene

 4133

UniProt

 P11137 (UniProt - Evidence at protein level)

neXtProt

 NX_P11137

Antibodypedia

 MAP2 antibodies

PROTEIN BROWSER
MAP2-001
MAP2-002
MAP2-003
MAP2-006
MAP2-008
MAP2-014
MAP2-015
MAP2-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP2-001
ENSP00000353508
ENST00000360351
P11137 [Direct mapping]
Microtubule-associated protein 2
A0A024R407 [Target identity:100%; Query identity:100%]
Microtubule-associated protein
Show all
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001578 [microtubule bundle formation]
GO:0002162 [dystroglycan binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0007409 [axonogenesis]
GO:0008017 [microtubule binding]
GO:0014069 [postsynaptic density]
GO:0015631 [tubulin binding]
GO:0016358 [dendrite development]
GO:0021954 [central nervous system neuron development]
GO:0031175 [neuron projection development]
GO:0034399 [nuclear periphery]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043198 [dendritic shaft]
GO:0044297 [cell body]
GO:0048813 [dendrite morphogenesis]
GO:0071310 [cellular response to organic substance]
GO:0097442 [CA3 pyramidal cell dendrite]
GO:0097481 [neuronal postsynaptic density]
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 1827 aa
199.5 kDa 		No 0
MAP2-002
ENSP00000376032
ENST00000392194
P11137 [Direct mapping]
Microtubule-associated protein 2
A0A024R409 [Target identity:100%; Query identity:100%]
Microtubule-associated protein
Show all
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0002162 [dystroglycan binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0021954 [central nervous system neuron development]
GO:0031175 [neuron projection development]
GO:0043005 [neuron projection]
GO:0048813 [dendrite morphogenesis]
Show all
 471 aa
49.6 kDa 		No 0
MAP2-003
ENSP00000199940
ENST00000199940
P11137 [Direct mapping]
Microtubule-associated protein 2
Show all
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0002162 [dystroglycan binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0021954 [central nervous system neuron development]
GO:0031175 [neuron projection development]
GO:0043005 [neuron projection]
GO:0048813 [dendrite morphogenesis]
Show all
 559 aa
59 kDa 		No 0
MAP2-006
ENSP00000376031
ENST00000392193
A8MZ31 [Direct mapping]
Microtubule-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0008017 [microtubule binding]
GO:0021954 [central nervous system neuron development]
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 106 aa
11.2 kDa 		No 0
MAP2-008
ENSP00000388824
ENST00000452717
H7BZB9 [Direct mapping]
Microtubule-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0008017 [microtubule binding]
GO:0021954 [central nervous system neuron development]
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 208 aa
21.8 kDa 		No 0
MAP2-014
ENSP00000392164
ENST00000447185
P11137 [Direct mapping]
Microtubule-associated protein 2
Show all
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0002162 [dystroglycan binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0021954 [central nervous system neuron development]
GO:0031175 [neuron projection development]
GO:0043005 [neuron projection]
GO:0048813 [dendrite morphogenesis]
Show all
 1823 aa
199.1 kDa 		No 0
MAP2-015
ENSP00000355290
ENST00000361559
P11137 [Direct mapping]
Microtubule-associated protein 2
A0A024R409 [Target identity:100%; Query identity:100%]
Microtubule-associated protein
Show all
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0002162 [dystroglycan binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0021954 [central nervous system neuron development]
GO:0031175 [neuron projection development]
GO:0043005 [neuron projection]
GO:0048813 [dendrite morphogenesis]
Show all
 471 aa
49.6 kDa 		No 0
MAP2-016
ENSP00000409969
ENST00000445941
E7EV03 [Direct mapping]
Microtubule-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001578 [microtubule bundle formation]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008017 [microtubule binding]
GO:0021954 [central nervous system neuron development]
Show all
 567 aa
61.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.