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ARAF

GENERAL INFORMATION

Gene name

 ARAF

Gene description

 A-Raf proto-oncogene, serine/threonine kinase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression, including gastrointestinal tract and lymphoid tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA066326
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA066326

GENE INFORMATION

Gene name

 ARAF (HGNC Symbol)

Synonyms

 ARAF1

Description

 A-Raf proto-oncogene, serine/threonine kinase (HGNC Symbol)

Entrez gene summary

 This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

Chromosome

 X

Cytoband

 p11.3

Chromosome location (bp)

 47561100 - 47571920

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078061 (version 83.38)

Entrez gene

 369

UniProt

 P10398 (UniProt - Evidence at protein level)

neXtProt

 NX_P10398

Antibodypedia

 ARAF antibodies

PROTEIN BROWSER
ARAF-001
ARAF-005
ARAF-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARAF-001
ENSP00000366244
ENST00000377045
P10398 [Direct mapping]
Serine/threonine-protein kinase A-Raf
A0A024R178 [Target identity:100%; Query identity:100%]
V-raf murine sarcoma 3611 viral oncogene homolog, isoform CRA_b
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0032006 [regulation of TOR signaling]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
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 606 aa
67.6 kDa 		No 0
ARAF-005
ENSP00000366238
ENST00000377039
P10398 [Direct mapping]
Serine/threonine-protein kinase A-Raf
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0032006 [regulation of TOR signaling]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
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 186 aa
20.9 kDa 		No 0
ARAF-201
ENSP00000290277
ENST00000290277
Q96II5 [Direct mapping]
ARAF protein; Serine/threonine-protein kinase A-Raf
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 609 aa
67.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.