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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ARAF
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ARAF

Gene description

A-Raf proto-oncogene, serine/threonine kinase

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression, including gastrointestinal tract and lymphoid tissue.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA066326
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ARAF (HGNC Symbol)

Synonyms

ARAF1

Description

A-Raf proto-oncogene, serine/threonine kinase (HGNC Symbol)

Entrez gene summary

This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

Chromosome

X

Cytoband

p11.3

Chromosome location (bp)

47561100 - 47571920

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078061 (version 83.38)

Entrez gene

369

UniProt

P10398 (UniProt - Evidence at protein level)

neXtProt

NX_P10398

Antibodypedia

ARAF antibodies

PROTEIN BROWSER

ARAF-001
ARAF-005
ARAF-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARAF-001
ENSP00000366244
ENST00000377045
P10398 [Direct mapping]
Serine/threonine-protein kinase A-Raf
A0A024R178 [Target identity:100%; Query identity:100%]
V-raf murine sarcoma 3611 viral oncogene homolog, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0032006 [regulation of TOR signaling]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
606 aa
67.6 kDa
No 0
ARAF-005
ENSP00000366238
ENST00000377039
P10398 [Direct mapping]
Serine/threonine-protein kinase A-Raf
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0032006 [regulation of TOR signaling]
GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
186 aa
20.9 kDa
No 0
ARAF-201
ENSP00000290277
ENST00000290277
Q96II5 [Direct mapping]
ARAF protein; Serine/threonine-protein kinase A-Raf
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
609 aa
67.9 kDa
No 0

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