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NEBL

GENERAL INFORMATION

Gene name

 NEBL

Gene description

 Nebulette

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle, thyroid gland)
GTEx:Tissue enhanced (heart muscle)
FANTOM5:Tissue enhanced (heart muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissues, most abundant in heart muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA013994 , HPA013995
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)

GENE INFORMATION

Gene name

 NEBL

Synonyms

Description

 Nebulette (HGNC Symbol)

Entrez gene summary

 This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

 10

Cytoband

 p12.31

Chromosome location (bp)

 20779973 - 21174187

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078114 (version 83.38)

Entrez gene

 10529

UniProt

 O76041 (UniProt - Evidence at protein level)

neXtProt

 NX_O76041

Antibodypedia

 NEBL antibodies

PROTEIN BROWSER
NEBL-001
NEBL-003
NEBL-004
NEBL-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEBL-001
ENSP00000489562
ENST00000473616
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 94 aa
10.7 kDa 		No 0
NEBL-003
ENSP00000393896
ENST00000417816
O76041 [Direct mapping]
Nebulette
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008270 [zinc ion binding]
GO:0008307 [structural constituent of muscle]
GO:0030018 [Z disc]
GO:0031005 [filamin binding]
GO:0031674 [I band]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0071691 [cardiac muscle thin filament assembly]
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 270 aa
31.2 kDa 		No 0
NEBL-004
ENSP00000366326
ENST00000377122
O76041 [Direct mapping]
Nebulette
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005523 [tropomyosin binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008307 [structural constituent of muscle]
GO:0030018 [Z disc]
GO:0031005 [filamin binding]
GO:0031674 [I band]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0071691 [cardiac muscle thin filament assembly]
Show all
 1014 aa
116.5 kDa 		No 0
NEBL-009
ENSP00000396512
ENST00000434381
Q5JUU7 [Direct mapping]
Nebulette
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 117 aa
13.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.