Expression of N4BP2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

N4BP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	N4BP2
Gene description	NEDD4 binding protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036770
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036770

GENE INFORMATION
Gene name	N4BP2 (HGNC Symbol)
Synonyms	B3BP
Description	NEDD4 binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p14
Chromosome location (bp)	40056826 - 40158252
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078177 (version 83.38)
Entrez gene	55728
UniProt	Q86UW6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UW6
Antibodypedia	N4BP2 antibodies

PROTEIN BROWSER

N4BP2-001	N4BP2-003	N4BP2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
N4BP2-001 ENSP00000261435 ENST00000261435	Q86UW6 [Direct mapping] NEDD4-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004519 [endonuclease activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0016310 [phosphorylation] GO:0046404 [ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	1770 aa 198.8 kDa	No	0
N4BP2-003 ENSP00000426430 ENST00000513269	H0YA93 [Direct mapping] NEDD4-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1400 aa 158.1 kDa	No	0
N4BP2-004 ENSP00000422057 ENST00000515550	D6R9J2 [Direct mapping] NEDD4-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 19 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.