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N4BP2

GENERAL INFORMATION

Gene name

 N4BP2

Gene description

 NEDD4 binding protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036770
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 N4BP2 (HGNC Symbol)

Synonyms

 B3BP

Description

 NEDD4 binding protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 40056826 - 40158252

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078177 (version 83.38)

Entrez gene

 55728

UniProt

 Q86UW6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86UW6

Antibodypedia

 N4BP2 antibodies

PROTEIN BROWSER
N4BP2-001
N4BP2-003
N4BP2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
N4BP2-001
ENSP00000261435
ENST00000261435
Q86UW6 [Direct mapping]
NEDD4-binding protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016310 [phosphorylation]
GO:0046404 [ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 1770 aa
198.8 kDa 		No 0
N4BP2-003
ENSP00000426430
ENST00000513269
H0YA93 [Direct mapping]
NEDD4-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1400 aa
158.1 kDa 		No 0
N4BP2-004
ENSP00000422057
ENST00000515550
D6R9J2 [Direct mapping]
NEDD4-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 173 aa
19 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.