Few cases of colorectal cancers showed distinct membranous and cytoplasmic immunoreactivity. Weak to moderate cytoplasmic and some times nuclear positivity was observed in few testicular, breast and prostate cancers. Remaining cancer cells were generally negative.
ADCYAP1R1 (HGNC Symbol)
PAC1, PAC1R, PACAPR
Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (HGNC Symbol)
Entrez gene summary
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]