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Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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ADCYAP1R1
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADCYAP1R1

Gene description

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

Protein class

G-protein coupled receptors
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Group enriched (AF22, NTERA-2, SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (cerebral cortex, fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in CNS and subset of cells in adrenal gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA049877
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA049877

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of colorectal cancers showed distinct membranous and cytoplasmic immunoreactivity. Weak to moderate cytoplasmic and some times nuclear positivity was observed in few testicular, breast and prostate cancers. Remaining cancer cells were generally negative.

GENE INFORMATION

Gene name

ADCYAP1R1 (HGNC Symbol)

Synonyms

PAC1, PAC1R, PACAPR

Description

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (HGNC Symbol)

Entrez gene summary

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

Chromosome

7

Cytoband

p14.3

Chromosome location (bp)

31052461 - 31111479

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078549 (version 83.38)

Entrez gene

117

UniProt

P41586 (UniProt - Evidence at protein level)

neXtProt

NX_P41586

Antibodypedia

ADCYAP1R1 antibodies

PROTEIN BROWSER

ADCYAP1R1-001
ADCYAP1R1-002
ADCYAP1R1-003
ADCYAP1R1-004
ADCYAP1R1-005
ADCYAP1R1-006
ADCYAP1R1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADCYAP1R1-001
ENSP00000306620
ENST00000304166
P41586 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
A0A090N8F8 [Target identity:100%; Query identity:100%]
Adenylate cyclase activating polypeptide 1 (Pituitary) receptor type I
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007283 [spermatogenesis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0043235 [receptor complex]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
468 aa
53.3 kDa
Yes 7
ADCYAP1R1-002
ENSP00000387335
ENST00000409363
P41586 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007283 [spermatogenesis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0043235 [receptor complex]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
447 aa
51 kDa
Yes 7
ADCYAP1R1-003
ENSP00000379514
ENST00000396211
P41586 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007283 [spermatogenesis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0043235 [receptor complex]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
496 aa
56.5 kDa
Yes 7
ADCYAP1R1-004
ENSP00000386395
ENST00000409489
E9PFU5 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
524 aa
59.6 kDa
Yes 7
ADCYAP1R1-005
ENSP00000416622
ENST00000436116
H0Y813 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
148 aa
16.5 kDa
No 3
ADCYAP1R1-006
ENSP00000400893
ENST00000431811
C9JVH3 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
Show all
74 aa
8.1 kDa
Yes 0
ADCYAP1R1-201
ENSP00000483721
ENST00000614107
P41586 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005791 [rough endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0005923 [bicellular tight junction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007202 [activation of phospholipase C activity]
GO:0007283 [spermatogenesis]
GO:0008179 [adenylate cyclase binding]
GO:0009986 [cell surface]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019933 [cAMP-mediated signaling]
GO:0030154 [cell differentiation]
GO:0030306 [ADP-ribosylation factor binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032355 [response to estradiol]
GO:0033555 [multicellular organismal response to stress]
GO:0042493 [response to drug]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0045471 [response to ethanol]
GO:0046545 [development of primary female sexual characteristics]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0060548 [negative regulation of cell death]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
Show all
496 aa
56.5 kDa
Yes 7

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The Human Protein Atlas project is funded
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