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ADCYAP1R1
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ADCYAP1R1

Gene description

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

Protein class

G-protein coupled receptors
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cerebral cortex, fallopian tube)
GTEx:Tissue enhanced (caudate, hypothalamus)
FANTOM5:Tissue enhanced (caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in CNS and subset of cells in adrenal gland.

DATA RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA049877
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebellum, hippocampus)

GENE INFORMATION

Gene name

ADCYAP1R1 (HGNC Symbol)

Synonyms

PAC1, PAC1R, PACAPR

Description

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (HGNC Symbol)

Entrez gene summary

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

Chromosome

7

Cytoband

p14.3

Chromosome location (bp)

31052461 - 31111479

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078549 (version 83.38)

Entrez gene

117

UniProt

P41586 (UniProt - Evidence at protein level)

neXtProt

NX_P41586

Antibodypedia

ADCYAP1R1 antibodies

PROTEIN BROWSER

ADCYAP1R1-001
ADCYAP1R1-002
ADCYAP1R1-003
ADCYAP1R1-004
ADCYAP1R1-005
ADCYAP1R1-006
ADCYAP1R1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADCYAP1R1-001
ENSP00000306620
ENST00000304166
P41586 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
A0A090N8F8 [Target identity:100%; Query identity:100%]
Adenylate cyclase activating polypeptide 1 (Pituitary) receptor type I
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007283 [spermatogenesis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0043235 [receptor complex]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
468 aa
53.3 kDa
Yes 7
ADCYAP1R1-002
ENSP00000387335
ENST00000409363
P41586 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007283 [spermatogenesis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0043235 [receptor complex]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
447 aa
51 kDa
Yes 7
ADCYAP1R1-003
ENSP00000379514
ENST00000396211
P41586 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007283 [spermatogenesis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0043235 [receptor complex]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
496 aa
56.5 kDa
Yes 7
ADCYAP1R1-004
ENSP00000386395
ENST00000409489
E9PFU5 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
524 aa
59.6 kDa
Yes 7
ADCYAP1R1-005
ENSP00000416622
ENST00000436116
H0Y813 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
148 aa
16.5 kDa
No 3
ADCYAP1R1-006
ENSP00000400893
ENST00000431811
C9JVH3 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
Show all
74 aa
8.1 kDa
Yes 0
ADCYAP1R1-201
ENSP00000483721
ENST00000614107
P41586 [Direct mapping]
Pituitary adenylate cyclase-activating polypeptide type I receptor
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004999 [vasoactive intestinal polypeptide receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005791 [rough endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0005923 [bicellular tight junction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007202 [activation of phospholipase C activity]
GO:0007283 [spermatogenesis]
GO:0008179 [adenylate cyclase binding]
GO:0009986 [cell surface]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019933 [cAMP-mediated signaling]
GO:0030154 [cell differentiation]
GO:0030306 [ADP-ribosylation factor binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0032355 [response to estradiol]
GO:0033555 [multicellular organismal response to stress]
GO:0042493 [response to drug]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0045471 [response to ethanol]
GO:0046545 [development of primary female sexual characteristics]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0060548 [negative regulation of cell death]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
Show all
496 aa
56.5 kDa
Yes 7

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