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TP73

GENERAL INFORMATION

Gene name

 TP73

Gene description

 Tumor protein p73

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (fallopian tube, skin)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in a subset of glandular cells in fallopian tube, squamous epithelium and respiratory epithelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
CAB002514 , CAB003022
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (fallopian tube, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 TP73 (HGNC Symbol)

Synonyms

 P73

Description

 Tumor protein p73 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

Chromosome

 1

Cytoband

 p36.32

Chromosome location (bp)

 3652520 - 3736201

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078900 (version 83.38)

Entrez gene

 7161

UniProt

 O15350 (UniProt - Evidence at protein level)

neXtProt

 NX_O15350

Antibodypedia

 TP73 antibodies

PROTEIN BROWSER
«
TP73-001
TP73-002
TP73-003
TP73-004
TP73-005
TP73-006
TP73-007
TP73-012
TP73-013
TP73-201
TP73-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TP73-001
ENSP00000367545
ENST00000378295
O15350 [Direct mapping]
Tumor protein p73
A0A024R4C3 [Target identity:100%; Query identity:100%]
Tumor protein p73, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000187 [activation of MAPK activity]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001822 [kidney development]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007050 [cell cycle arrest]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009791 [post-embryonic development]
GO:0010165 [response to X-ray]
GO:0010243 [response to organonitrogen compound]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0021766 [hippocampus development]
GO:0030054 [cell junction]
GO:0030900 [forebrain development]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0033326 [cerebrospinal fluid secretion]
GO:0034644 [cellular response to UV]
GO:0042493 [response to drug]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045793 [positive regulation of cell size]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048546 [digestive tract morphogenesis]
GO:0048666 [neuron development]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
GO:1902167 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 636 aa
69.6 kDa 		No 0
TP73-002
ENSP00000346423
ENST00000354437
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 499 aa
54.3 kDa 		No 0
TP73-003
ENSP00000367537
ENST00000378288
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 587 aa
64.4 kDa 		No 0
TP73-004
ENSP00000367534
ENST00000378285
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 450 aa
49.1 kDa 		No 0
TP73-005
ENSP00000367529
ENST00000378280
A0A0C4DFW9 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
Show all
 426 aa
47.7 kDa 		No 0
TP73-006
ENSP00000475143
ENST00000604074
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 403 aa
44.5 kDa 		No 0
TP73-007
ENSP00000367539
ENST00000378290
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 565 aa
62 kDa 		No 0
TP73-012
ENSP00000474626
ENST00000603362
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 555 aa
61.7 kDa 		No 0
TP73-013
ENSP00000474322
ENST00000604479
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 540 aa
59.9 kDa 		No 0
TP73-201
ENSP00000340740
ENST00000346387
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 540 aa
59.9 kDa 		No 0
TP73-202
ENSP00000350366
ENST00000357733
O15350 [Direct mapping]
Tumor protein p73
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0071158 [positive regulation of cell cycle arrest]
Show all
 555 aa
61.7 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.