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TOLLIP

GENERAL INFORMATION

Gene name

 TOLLIP

Gene description

 Toll interacting protein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, highest levels in the brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

 Supported based on 2 antibodies.
HPA038621 , HPA038622
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and glioma (unfavourable).
Renal cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038621
HPA038622

GENE INFORMATION

Gene name

 TOLLIP (HGNC Symbol)

Synonyms

 IL-1RAcPIP

Description

 Toll interacting protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 1274371 - 1309654

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000078902 (version 83.38)

Entrez gene

 54472

UniProt

 Q9H0E2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0E2

Antibodypedia

 TOLLIP antibodies

PROTEIN BROWSER
TOLLIP-001
TOLLIP-002
TOLLIP-003
TOLLIP-004
TOLLIP-005
TOLLIP-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOLLIP-001
ENSP00000314733
ENST00000317204
Q9H0E2 [Direct mapping]
Toll-interacting protein
Q6FIE9 [Target identity:100%; Query identity:100%]
TOLLIP protein; Toll interacting protein; Toll interacting protein, isoform CRA_a; cDNA, FLJ96670, Homo sapiens toll interacting protein (TOLLIP), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004871 [signal transducer activity]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0016310 [phosphorylation]
GO:0016604 [nuclear body]
GO:0019900 [kinase binding]
GO:0030855 [epithelial cell differentiation]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032183 [SUMO binding]
GO:0033235 [positive regulation of protein sumoylation]
GO:0035325 [Toll-like receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0036010 [protein localization to endosome]
GO:0045087 [innate immune response]
GO:0045092 [interleukin-18 receptor complex]
GO:0045321 [leukocyte activation]
GO:0045323 [interleukin-1 receptor complex]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 274 aa
30.3 kDa 		No 0
TOLLIP-002
ENSP00000434035
ENST00000527886
Q9H0E2 [Direct mapping]
Toll-interacting protein
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0016310 [phosphorylation]
GO:0019900 [kinase binding]
GO:0030855 [epithelial cell differentiation]
GO:0035325 [Toll-like receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0036010 [protein localization to endosome]
GO:0045087 [innate immune response]
GO:0045092 [interleukin-18 receptor complex]
GO:0045321 [leukocyte activation]
GO:0045323 [interleukin-1 receptor complex]
GO:0070062 [extracellular exosome]
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 205 aa
22.8 kDa 		No 0
TOLLIP-003
ENSP00000432668
ENST00000525159
F2Z2Y8 [Direct mapping]
Toll-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 213 aa
23.3 kDa 		No 0
TOLLIP-004
ENSP00000263646
ENST00000263646
E7EN89 [Direct mapping]
Toll interacting protein, isoform CRA_b; Toll-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 246 aa
27 kDa 		No 0
TOLLIP-005
ENSP00000434494
ENST00000530541
E9PQ25 [Direct mapping]
Toll-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 186 aa
20.5 kDa 		No 0
TOLLIP-012
ENSP00000432778
ENST00000527938
E9PNS3 [Direct mapping]
Toll-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 80 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.