Expression of UBE2D4 in cancer - Summary - The Human Protein Atlas

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UBE2D4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UBE2D4
Gene description	Ubiquitin-conjugating enzyme E2D 4 (putative)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA003920
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), prostate cancer (favourable) and renal cancer (favourable).
Pancreatic cancer p<0.001 Prostate cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003920

GENE INFORMATION
Gene name	UBE2D4 (HGNC Symbol)
Synonyms	HBUCE1
Description	Ubiquitin-conjugating enzyme E2D 4 (putative) (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p13
Chromosome location (bp)	43926438 - 43956136
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000078967 (version 83.38)
Entrez gene	51619
UniProt	Q9Y2X8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2X8
Antibodypedia	UBE2D4 antibodies

PROTEIN BROWSER

UBE2D4-001	UBE2D4-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBE2D4-001 ENSP00000222402 ENST00000222402	Q9Y2X8 [Direct mapping] Ubiquitin-conjugating enzyme E2 D4 A0A024RA90 [Target identity:100%; Query identity:100%] Ubiquitin-conjugating enzyme E2D 4 (Putative), isoform CRA_e Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0016567 [protein ubiquitination] GO:0035519 [protein K29-linked ubiquitination] GO:0044314 [protein K27-linked ubiquitination] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0070979 [protein K11-linked ubiquitination] GO:0085020 [protein K6-linked ubiquitination] Show all	147 aa 16.6 kDa	No	0
UBE2D4-009 ENSP00000397406 ENST00000446008	C9J9H9 [Direct mapping] Ubiquitin-conjugating enzyme E2 D4 Show all	Predicted intracellular proteins Show all	GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016874 [ligase activity] Show all	122 aa 13.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.