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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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UBE2D4
  • TISSUE

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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

UBE2D4

Gene description

Ubiquitin-conjugating enzyme E2D 4 (putative)

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Approved based on 1 antibody.
HPA003920
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PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (favourable), prostate cancer (favourable) and renal cancer (favourable).
Pancreatic cancer p<0.001
Prostate cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA003920

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate nuclear membrane positivity.

GENE INFORMATION

Gene name

UBE2D4 (HGNC Symbol)

Synonyms

HBUCE1

Description

Ubiquitin-conjugating enzyme E2D 4 (putative) (HGNC Symbol)

Entrez gene summary

Chromosome

7

Cytoband

p13

Chromosome location (bp)

43926438 - 43956136

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078967 (version 83.38)

Entrez gene

51619

UniProt

Q9Y2X8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2X8

Antibodypedia

UBE2D4 antibodies

PROTEIN BROWSER

UBE2D4-001
UBE2D4-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2D4-001
ENSP00000222402
ENST00000222402
Q9Y2X8 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D4
A0A024RA90 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2D 4 (Putative), isoform CRA_e
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0016567 [protein ubiquitination]
GO:0035519 [protein K29-linked ubiquitination]
GO:0044314 [protein K27-linked ubiquitination]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0085020 [protein K6-linked ubiquitination]
Show all
147 aa
16.6 kDa
No 0
UBE2D4-009
ENSP00000397406
ENST00000446008
C9J9H9 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D4
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Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
122 aa
13.6 kDa
No 0

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