Cell atlas - CDH17 - The Human Protein Atlas

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CDH17

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CDH17
Gene description	Cadherin 17, LI cadherin (liver-intestine)
Protein class	Cancer-related genes Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cell junctions.
RNA cell category	Group enriched (U-266/70, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA023616 , HPA026556
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-266/70, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cell junctions.

Main location

Cell Junctions (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023616	A549	No staining
	HPA023616	CACO-2	Cell Junctions
	HPA026556	A549	Nucleus
	HPA026556	A549	Cell Junctions
	HPA026556	CACO-2	Cell Junctions

GENE INFORMATION
Gene name	CDH17 (HGNC Symbol)
Synonyms	cadherin, HPT-1
Description	Cadherin 17, LI cadherin (liver-intestine) (HGNC Symbol)
Entrez gene summary	This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Chromosome	8
Cytoband	q22.1
Chromosome location (bp)	94127171 - 94217303
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079112 (version 83.38)
Entrez gene	1015
UniProt	Q12864 (UniProt - Evidence at transcript level)
neXtProt	NX_Q12864
Antibodypedia	CDH17 antibodies

PROTEIN BROWSER

CDH17-001	CDH17-002	CDH17-003	CDH17-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDH17-001 ENSP00000027335 ENST00000027335	Q12864 [Direct mapping] Cadherin-17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005427 [proton-dependent oligopeptide secondary active transmembrane transporter activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006857 [oligopeptide transport] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0035672 [oligopeptide transmembrane transport] GO:0045216 [cell-cell junction organization] Show all	832 aa 92.2 kDa	Yes	1
CDH17-002 ENSP00000392811 ENST00000441892	E7EN24 [Direct mapping] Cadherin-17 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	580 aa 64.2 kDa	Yes	0
CDH17-003 ENSP00000401468 ENST00000450165	Q12864 [Direct mapping] Cadherin-17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005427 [proton-dependent oligopeptide secondary active transmembrane transporter activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006857 [oligopeptide transport] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0035672 [oligopeptide transmembrane transport] GO:0045216 [cell-cell junction organization] Show all	832 aa 92.2 kDa	Yes	1
CDH17-004 ENSP00000428189 ENST00000521491	E5RJT3 [Direct mapping] Cadherin-17 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] Show all	147 aa 16.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.