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FKBP7

GENERAL INFORMATION

Gene name

 FKBP7

Gene description

 FK506 binding protein 7

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Tissue enhanced (ovary)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA008707
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008707

GENE INFORMATION

Gene name

 FKBP7 (HGNC Symbol)

Synonyms

 FKBP23

Description

 FK506 binding protein 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.2

Chromosome location (bp)

 178463664 - 178478600

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079150 (version 83.38)

Entrez gene

 51661

UniProt

 Q9Y680 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y680

Antibodypedia

 FKBP7 antibodies

PROTEIN BROWSER
FKBP7-001
FKBP7-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP7-001
ENSP00000413152
ENST00000424785
Q9Y680 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP7
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Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
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 222 aa
25.8 kDa 		Yes 0
FKBP7-008
ENSP00000415486
ENST00000434643
Q9Y680 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP7
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Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
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 221 aa
25.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.