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Occasional cystadenocarcinomas of ovary and malignant gliomas along a with rare case of malignant melanoma, thyroid and gastric cancers displayed weak to moderate cytoplasmic staining. Other malignant cells along with stromal cells were negative.
Malignant cells were negative. Stroma of malignant gliomas showed distinct immunoreactivity.
GENE INFORMATION
Gene name
SLC1A3 (HGNC Symbol)
Synonyms
EA6, EAAT1, GLAST
Description
Solute carrier family 1 (glial high affinity glutamate transporter), member 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]