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SP140

GENERAL INFORMATION

Gene name

 SP140

Gene description

 SP140 nuclear body protein

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (Daudi, HDLM-2, Karpas-707)
HPA (normal tissue):Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective nuclear expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006162 , HPA067493
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA006162
HPA067493

GENE INFORMATION

Gene name

 SP140 (HGNC Symbol)

Synonyms

 LYSP100-A, LYSP100-B

Description

 SP140 nuclear body protein (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 230203110 - 230313215

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079263 (version 83.38)

Entrez gene

 11262

UniProt

 Q13342 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13342

Antibodypedia

 SP140 antibodies

PROTEIN BROWSER
SP140-002
SP140-003
SP140-004
SP140-009
SP140-015
SP140-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SP140-002
ENSP00000375899
ENST00000392045
Q13342 [Direct mapping]
Nuclear body protein SP140
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Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006952 [defense response]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
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 867 aa
98.2 kDa 		No 0
SP140-003
ENSP00000362749
ENST00000373645
Q13342 [Direct mapping]
Nuclear body protein SP140
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Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006952 [defense response]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
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 172 aa
20 kDa 		No 0
SP140-004
ENSP00000393618
ENST00000417495
Q13342 [Direct mapping]
Nuclear body protein SP140
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006952 [defense response]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
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 753 aa
86 kDa 		No 0
SP140-009
ENSP00000342096
ENST00000343805
Q13342 [Direct mapping]
Nuclear body protein SP140
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006952 [defense response]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
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 807 aa
91.7 kDa 		No 0
SP140-015
ENSP00000475284
ENST00000456542
U3KPV9 [Direct mapping]
Nuclear body protein SP140
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
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 29 aa
3.3 kDa 		No 0
SP140-201
ENSP00000398210
ENST00000420434
Q13342 [Direct mapping]
Nuclear body protein SP140
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006952 [defense response]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
Show all
 840 aa
95.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.