Cell atlas - CDC14A - The Human Protein Atlas

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CDC14A

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDC14A
Gene description	Cell division cycle 14A
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & nuclear bodies.
RNA cell category	Cell line enhanced (K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Nuclear bodies (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA023783
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & nuclear bodies.

Main location

Nucleoplasm (supported)

Additional location

Nuclear bodies (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023783	A-431	Nucleoplasm
			Nuclear bodies
			Cytosol
	HPA023783	U-2 OS	Nucleoplasm
	HPA023783	U-2 OS	Cytosol
	HPA023783	U-251 MG	Nucleoplasm
	HPA023783	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CDC14A (HGNC Symbol)
Synonyms	cdc14, Cdc14A1, Cdc14A2
Description	Cell division cycle 14A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p21.2
Chromosome location (bp)	100345025 - 100520277
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000079335 (version 83.38)
Entrez gene	8556
UniProt	Q9UNH5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNH5
Antibodypedia	CDC14A antibodies

PROTEIN BROWSER

CDC14A-001	CDC14A-002	CDC14A-003	CDC14A-004	CDC14A-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDC14A-001 ENSP00000336739 ENST00000336454	Q9UNH5 [Direct mapping] Dual specificity protein phosphatase CDC14A Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0000922 [spindle pole] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006470 [protein dephosphorylation] GO:0007096 [regulation of exit from mitosis] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0008283 [cell proliferation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042384 [cilium assembly] GO:0051256 [mitotic spindle midzone assembly] GO:0051301 [cell division] GO:0071850 [mitotic cell cycle arrest] GO:0072686 [mitotic spindle] Show all	594 aa 66.6 kDa	No	0
CDC14A-002 ENSP00000354916 ENST00000361544	Q9UNH5 [Direct mapping] Dual specificity protein phosphatase CDC14A Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0000922 [spindle pole] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006470 [protein dephosphorylation] GO:0007096 [regulation of exit from mitosis] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0008283 [cell proliferation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042384 [cilium assembly] GO:0051256 [mitotic spindle midzone assembly] GO:0051301 [cell division] GO:0071850 [mitotic cell cycle arrest] GO:0072686 [mitotic spindle] Show all	623 aa 69.5 kDa	No	0
CDC14A-003 ENSP00000359142 ENST00000370124	Q9UNH5 [Direct mapping] Dual specificity protein phosphatase CDC14A Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0000922 [spindle pole] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006470 [protein dephosphorylation] GO:0007096 [regulation of exit from mitosis] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0008283 [cell proliferation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042384 [cilium assembly] GO:0051256 [mitotic spindle midzone assembly] GO:0051301 [cell division] GO:0071850 [mitotic cell cycle arrest] GO:0072686 [mitotic spindle] Show all	383 aa 43.9 kDa	No	0
CDC14A-004 ENSP00000388501 ENST00000455467	C9JSP6 [Direct mapping] Dual-specificity protein phosphatase CDC14A Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		273 aa 31.8 kDa	No	0
CDC14A-006 ENSP00000489217 ENST00000635056		SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	565 aa 62.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.