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CDC14A

GENERAL INFORMATION

Gene name

 CDC14A

Gene description

 Cell division cycle 14A

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (K-562)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023783
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023783

GENE INFORMATION

Gene name

 CDC14A (HGNC Symbol)

Synonyms

 cdc14, Cdc14A1, Cdc14A2

Description

 Cell division cycle 14A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p21.2

Chromosome location (bp)

 100345025 - 100520277

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079335 (version 83.38)

Entrez gene

 8556

UniProt

 Q9UNH5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNH5

Antibodypedia

 CDC14A antibodies

PROTEIN BROWSER
CDC14A-001
CDC14A-002
CDC14A-003
CDC14A-004
CDC14A-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC14A-001
ENSP00000336739
ENST00000336454
Q9UNH5 [Direct mapping]
Dual specificity protein phosphatase CDC14A
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000922 [spindle pole]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006470 [protein dephosphorylation]
GO:0007096 [regulation of exit from mitosis]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008283 [cell proliferation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042384 [cilium assembly]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051301 [cell division]
GO:0071850 [mitotic cell cycle arrest]
GO:0072686 [mitotic spindle]
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 594 aa
66.6 kDa 		No 0
CDC14A-002
ENSP00000354916
ENST00000361544
Q9UNH5 [Direct mapping]
Dual specificity protein phosphatase CDC14A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000922 [spindle pole]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006470 [protein dephosphorylation]
GO:0007096 [regulation of exit from mitosis]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008283 [cell proliferation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042384 [cilium assembly]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051301 [cell division]
GO:0071850 [mitotic cell cycle arrest]
GO:0072686 [mitotic spindle]
Show all
 623 aa
69.5 kDa 		No 0
CDC14A-003
ENSP00000359142
ENST00000370124
Q9UNH5 [Direct mapping]
Dual specificity protein phosphatase CDC14A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000922 [spindle pole]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006470 [protein dephosphorylation]
GO:0007096 [regulation of exit from mitosis]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008283 [cell proliferation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042384 [cilium assembly]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051301 [cell division]
GO:0071850 [mitotic cell cycle arrest]
GO:0072686 [mitotic spindle]
Show all
 383 aa
43.9 kDa 		No 0
CDC14A-004
ENSP00000388501
ENST00000455467
C9JSP6 [Direct mapping]
Dual-specificity protein phosphatase CDC14A
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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 273 aa
31.8 kDa 		No 0
CDC14A-006
ENSP00000489217
ENST00000635056
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
 565 aa
62.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.