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PGM1

GENERAL INFORMATION

Gene name

 PGM1

Gene description

 Phosphoglucomutase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types. Cytoplasmic and nuclear expression in hepatocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 4 antibodies.
HPA024190 , HPA024637 , HPA046329 , CAB004666
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024190
HPA024637
HPA046329
CAB004666

GENE INFORMATION

Gene name

 PGM1

Synonyms

Description

 Phosphoglucomutase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 63593276 - 63660245

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079739 (version 83.38)

Entrez gene

 5236

UniProt

 P36871 (UniProt - Evidence at protein level)

neXtProt

 NX_P36871

Antibodypedia

 PGM1 antibodies

PROTEIN BROWSER
PGM1-001
PGM1-002
PGM1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGM1-001
ENSP00000360125
ENST00000371084
P36871 [Direct mapping]
Phosphoglucomutase-1
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Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004614 [phosphoglucomutase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0015629 [actin cytoskeleton]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0019388 [galactose catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071704 [organic substance metabolic process]
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 562 aa
61.4 kDa 		No 0
PGM1-002
ENSP00000360124
ENST00000371083
P36871 [Direct mapping]
Phosphoglucomutase-1
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Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004614 [phosphoglucomutase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0009314 [response to radiation]
GO:0015629 [actin cytoskeleton]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0019388 [galactose catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071704 [organic substance metabolic process]
Show all
 580 aa
63.8 kDa 		No 0
PGM1-201
ENSP00000443449
ENST00000540265
P36871 [Direct mapping]
Phosphoglucomutase-1
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004614 [phosphoglucomutase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0015629 [actin cytoskeleton]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0019388 [galactose catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071704 [organic substance metabolic process]
Show all
 365 aa
40.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.