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PGM1

GENERAL INFORMATION

Gene name

 PGM1

Gene description

 Phosphoglucomutase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types. Cytoplasmic and nuclear expression in hepatocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 4 antibodies.
HPA024190 , HPA024637 , HPA046329 , CAB004666
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PGM1

Synonyms

Description

 Phosphoglucomutase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 63593276 - 63660245

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079739 (version 83.38)

Entrez gene

 5236

UniProt

 P36871 (UniProt - Evidence at protein level)

neXtProt

 NX_P36871

Antibodypedia

 PGM1 antibodies

PROTEIN BROWSER
PGM1-001
PGM1-002
PGM1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGM1-001
ENSP00000360125
ENST00000371084
P36871 [Direct mapping]
Phosphoglucomutase-1
Show all
Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004614 [phosphoglucomutase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0015629 [actin cytoskeleton]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0019388 [galactose catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071704 [organic substance metabolic process]
Show all
 562 aa
61.4 kDa 		No 0
PGM1-002
ENSP00000360124
ENST00000371083
P36871 [Direct mapping]
Phosphoglucomutase-1
Show all
Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004614 [phosphoglucomutase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0009314 [response to radiation]
GO:0015629 [actin cytoskeleton]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0019388 [galactose catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071704 [organic substance metabolic process]
Show all
 580 aa
63.8 kDa 		No 0
PGM1-201
ENSP00000443449
ENST00000540265
P36871 [Direct mapping]
Phosphoglucomutase-1
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004614 [phosphoglucomutase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0005980 [glycogen catabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0015629 [actin cytoskeleton]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0019388 [galactose catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071704 [organic substance metabolic process]
Show all
 365 aa
40.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.