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DDX1

GENERAL INFORMATION

Gene name

 DDX1

Gene description

 DEAD (Asp-Glu-Ala-Asp) box helicase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA034502 , HPA034503 , CAB012280
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA034502
HPA034503
CAB012280

GENE INFORMATION

Gene name

 DDX1 (HGNC Symbol)

Synonyms

 DBP-RB

Description

 DEAD (Asp-Glu-Ala-Asp) box helicase 1 (HGNC Symbol)

Entrez gene summary

 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p24.3

Chromosome location (bp)

 15591178 - 15631111

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000079785 (version 83.38)

Entrez gene

 1653

UniProt

 Q92499 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92499

Antibodypedia

 DDX1 antibodies

PROTEIN BROWSER
DDX1-001
DDX1-002
DDX1-201
DDX1-202
DDX1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX1-001
ENSP00000370745
ENST00000381341
Q92499 [Direct mapping]
ATP-dependent RNA helicase DDX1
A3RJH1 [Target identity:100%; Query identity:100%]
ATP-dependent RNA helicase DDX1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1, isoform CRA_d; DEAD box polypeptide 1; cDNA, FLJ94573, Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 (DDX1), mRNA
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003712 [transcription cofactor activity]
GO:0003724 [RNA helicase activity]
GO:0003725 [double-stranded RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004518 [nuclease activity]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006446 [regulation of translational initiation]
GO:0007275 [multicellular organismal development]
GO:0008026 [ATP-dependent helicase activity]
GO:0008033 [tRNA processing]
GO:0008143 [poly(A) binding]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0032508 [DNA duplex unwinding]
GO:0033677 [DNA/RNA helicase activity]
GO:0043330 [response to exogenous dsRNA]
GO:0044822 [poly(A) RNA binding]
GO:0071920 [cleavage body]
GO:0072669 [tRNA-splicing ligase complex]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 740 aa
82.4 kDa 		No 0
DDX1-002
ENSP00000413767
ENST00000434671
C9JLP0 [Direct mapping]
ATP-dependent RNA helicase DDX1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004004 [ATP-dependent RNA helicase activity]
GO:0010501 [RNA secondary structure unwinding]
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 16 aa
1.7 kDa 		No 0
DDX1-201
ENSP00000233084
ENST00000233084
Q92499 [Direct mapping]
ATP-dependent RNA helicase DDX1
A3RJH1 [Target identity:100%; Query identity:100%]
ATP-dependent RNA helicase DDX1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1, isoform CRA_d; DEAD box polypeptide 1; cDNA, FLJ94573, Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 (DDX1), mRNA
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003712 [transcription cofactor activity]
GO:0003724 [RNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004518 [nuclease activity]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006446 [regulation of translational initiation]
GO:0007275 [multicellular organismal development]
GO:0008026 [ATP-dependent helicase activity]
GO:0008033 [tRNA processing]
GO:0008143 [poly(A) binding]
GO:0010467 [gene expression]
GO:0010494 [cytoplasmic stress granule]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0032508 [DNA duplex unwinding]
GO:0033677 [DNA/RNA helicase activity]
GO:0044822 [poly(A) RNA binding]
GO:0071920 [cleavage body]
GO:0072669 [tRNA-splicing ligase complex]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 740 aa
82.4 kDa 		No 0
DDX1-202
ENSP00000482416
ENST00000617198
F1T0B3 [Direct mapping]
ATP-dependent RNA helicase DDX1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0010501 [RNA secondary structure unwinding]
Show all
 659 aa
73.9 kDa 		No 0
DDX1-203
ENSP00000484958
ENST00000621973
A0A087X2G1 [Direct mapping]
ATP-dependent RNA helicase DDX1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0010501 [RNA secondary structure unwinding]
Show all
 659 aa
74 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.