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EPHA6

GENERAL INFORMATION

Gene name

 EPHA6

Gene description

 EPH receptor A6

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEK93, U-266/70)
HPA (normal tissue):Tissue enhanced (ovary, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA007397
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007397

GENE INFORMATION

Gene name

 EPHA6 (HGNC Symbol)

Synonyms

 FLJ35246

Description

 EPH receptor A6 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q11.2

Chromosome location (bp)

 96814581 - 97752460

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000080224 (version 83.38)

Entrez gene

 285220

UniProt

 Q9UF33 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UF33

Antibodypedia

 EPHA6 antibodies

PROTEIN BROWSER
EPHA6-001
EPHA6-002
EPHA6-005
EPHA6-006
EPHA6-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPHA6-001
ENSP00000420598
ENST00000470610
E7EU71 [Direct mapping]
Ephrin type-A receptor 6
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0005003 [ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016021 [integral component of membrane]
GO:0048013 [ephrin receptor signaling pathway]
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 547 aa
61 kDa 		No 0
EPHA6-002
ENSP00000374323
ENST00000389672
A0A0B4J1T8 [Direct mapping]
Receptor protein-tyrosine kinase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
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 1130 aa
126.6 kDa 		No 2
EPHA6-005
ENSP00000425132
ENST00000506569
H0Y9V0 [Direct mapping]
Ephrin type-A receptor 6
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
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GO:0005003 [ephrin receptor activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016021 [integral component of membrane]
GO:0048013 [ephrin receptor signaling pathway]
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 324 aa
37.1 kDa 		No 0
EPHA6-006
ENSP00000423950
ENST00000502694
Q9UF33 [Direct mapping]
Ephrin type-A receptor 6
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0003674 [molecular_function]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007411 [axon guidance]
GO:0008150 [biological_process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
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 334 aa
37.3 kDa 		No 1
EPHA6-007
ENSP00000421711
ENST00000514100
Q9UF33 [Direct mapping]
Ephrin type-A receptor 6
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0003674 [molecular_function]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007411 [axon guidance]
GO:0008150 [biological_process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 398 aa
44.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.