Tissue expression of EPHA6 - Summary - The Human Protein Atlas

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EPHA6

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	EPHA6
Gene description	EPH receptor A6
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (ovary, testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enhanced (caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA007397
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, cerebellum, hippocampus)

GENE INFORMATION
Gene name	EPHA6 (HGNC Symbol)
Synonyms	FLJ35246
Description	EPH receptor A6 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q11.2
Chromosome location (bp)	96814581 - 97752460
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080224 (version 83.38)
Entrez gene	285220
UniProt	Q9UF33 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UF33
Antibodypedia	EPHA6 antibodies

PROTEIN BROWSER

EPHA6-001	EPHA6-002	EPHA6-005	EPHA6-006	EPHA6-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPHA6-001 ENSP00000420598 ENST00000470610	E7EU71 [Direct mapping] Ephrin type-A receptor 6 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0048013 [ephrin receptor signaling pathway] Show all	547 aa 61 kDa	No	0
EPHA6-002 ENSP00000374323 ENST00000389672	A0A0B4J1T8 [Direct mapping] Receptor protein-tyrosine kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	1130 aa 126.6 kDa	No	2
EPHA6-005 ENSP00000425132 ENST00000506569	H0Y9V0 [Direct mapping] Ephrin type-A receptor 6 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005003 [ephrin receptor activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0048013 [ephrin receptor signaling pathway] Show all	324 aa 37.1 kDa	No	0
EPHA6-006 ENSP00000423950 ENST00000502694	Q9UF33 [Direct mapping] Ephrin type-A receptor 6 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0008150 [biological_process] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	334 aa 37.3 kDa	No	1
EPHA6-007 ENSP00000421711 ENST00000514100	Q9UF33 [Direct mapping] Ephrin type-A receptor 6 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0008150 [biological_process] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway] Show all	398 aa 44.5 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.