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RDH8

GENERAL INFORMATION

Gene name

 RDH8

Gene description

 Retinol dehydrogenase 8 (all-trans)

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (melanoma, stomach cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (kidney, testis)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (melanoma, stomach cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RDH8 (HGNC Symbol)

Synonyms

 PRRDH, SDR28C2

Description

 Retinol dehydrogenase 8 (all-trans) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. [provided by RefSeq, Feb 2014]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10013249 - 10022279

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000080511 (version 83.38)

Entrez gene

 50700

UniProt

neXtProt

Antibodypedia

 RDH8 antibodies

PROTEIN BROWSER
RDH8-001
RDH8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RDH8-001
ENSP00000466058
ENST00000591589
K7ELF7 [Direct mapping]
Retinol dehydrogenase 8
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0004303 [estradiol 17-beta-dehydrogenase activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0006703 [estrogen biosynthetic process]
GO:0007601 [visual perception]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0042572 [retinol metabolic process]
GO:0055114 [oxidation-reduction process]
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 331 aa
35.8 kDa 		No 0
RDH8-002
ENSP00000465773
ENST00000587782
K7EKT5 [Direct mapping]
Retinol dehydrogenase 8
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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 79 aa
8.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.