Tissue expression of SESN1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SESN1
Gene description	Sestrin 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SESN1 (HGNC Symbol)
Synonyms	PA26, SEST1
Description	Sestrin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	108986437 - 109094819
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080546 (version 83.38)
Entrez gene	27244
UniProt	Q9Y6P5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6P5
Antibodypedia	SESN1 antibodies

PROTEIN BROWSER

SESN1-001	SESN1-002	SESN1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SESN1-001 ENSP00000393762 ENST00000436639	Q9Y6P5 [Direct mapping] Sestrin-1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0051896 [regulation of protein kinase B signaling] GO:1901031 [regulation of response to reactive oxygen species] Show all	551 aa 63.8 kDa	No	0
SESN1-002 ENSP00000349061 ENST00000356644	Q9Y6P5 [Direct mapping] Sestrin-1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:1901031 [regulation of response to reactive oxygen species] Show all	492 aa 56.6 kDa	No	0
SESN1-003 ENSP00000306734 ENST00000302071	Q9Y6P5 [Direct mapping] Sestrin-1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:1901031 [regulation of response to reactive oxygen species] Show all	426 aa 49.6 kDa	No	0