Expression of DLGAP4 in cancer - Summary - The Human Protein Atlas

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DLGAP4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DLGAP4
Gene description	Discs, large (Drosophila) homolog-associated protein 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA054105
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable), melanoma (favourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Melanoma p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054105

GENE INFORMATION
Gene name	DLGAP4 (HGNC Symbol)
Synonyms	DAP4, KIAA0964, SAPAP4
Description	Discs, large (Drosophila) homolog-associated protein 4 (HGNC Symbol)
Entrez gene summary	The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	36306336 - 36528637
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080845 (version 83.38)
Entrez gene	22839
UniProt	Q9Y2H0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2H0
Antibodypedia	DLGAP4 antibodies

PROTEIN BROWSER

DLGAP4-001	DLGAP4-005	DLGAP4-007	DLGAP4-008	DLGAP4-009	DLGAP4-011	DLGAP4-015	DLGAP4-201	DLGAP4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLGAP4-001 ENSP00000484696 ENST00000495241	A0A087X246 [Direct mapping] Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0023052 [signaling] Show all	125 aa 13.8 kDa	No	0
DLGAP4-005 ENSP00000363023 ENST00000373913	Q9Y2H0 [Direct mapping] Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] GO:0023052 [signaling] GO:0045202 [synapse] Show all	989 aa 107.6 kDa	No	0
DLGAP4-007 ENSP00000363014 ENST00000373907	Q9Y2H0 [Direct mapping] Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] GO:0023052 [signaling] Show all	992 aa 108 kDa	No	0
DLGAP4-008 ENSP00000345700 ENST00000340491	Q9Y2H0 [Direct mapping] Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] GO:0023052 [signaling] Show all	453 aa 49.5 kDa	No	0
DLGAP4-009 ENSP00000477723 ENST00000475894	A0A0B4J2C2 [Direct mapping] Discs, large (Drosophila) homolog-associated protein 4, isoform CRA_b; Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0023052 [signaling] Show all	285 aa 31.7 kDa	No	0
DLGAP4-011 ENSP00000480166 ENST00000482872	A0A087WWE6 [Direct mapping] Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 4.9 kDa	No	0
DLGAP4-015 ENSP00000419311 ENST00000489701	F8WF49 [Direct mapping] Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0023052 [signaling] Show all	244 aa 26.9 kDa	No	0
DLGAP4-201 ENSP00000341633 ENST00000339266	Q9Y2H0 [Direct mapping] Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] GO:0023052 [signaling] Show all	992 aa 108 kDa	No	0
DLGAP4-202 ENSP00000384954 ENST00000401952	Q9Y2H0 [Direct mapping] Disks large-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016020 [membrane] GO:0023052 [signaling] Show all	989 aa 107.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.