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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

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Score

Score

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Antibodies

Column

 
 
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DLGAP4
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

DLGAP4

Gene description

Discs, large (Drosophila) homolog-associated protein 4

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA054105
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

DLGAP4 (HGNC Symbol)

Synonyms

DAP4, KIAA0964, SAPAP4

Description

Discs, large (Drosophila) homolog-associated protein 4 (HGNC Symbol)

Entrez gene summary

The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q11.23

Chromosome location (bp)

36306336 - 36528637

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080845 (version 83.38)

Entrez gene

22839

UniProt

Q9Y2H0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2H0

Antibodypedia

DLGAP4 antibodies

PROTEIN BROWSER

DLGAP4-001
DLGAP4-005
DLGAP4-007
DLGAP4-008
DLGAP4-009
DLGAP4-011
DLGAP4-015
DLGAP4-201
DLGAP4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DLGAP4-001
ENSP00000484696
ENST00000495241
A0A087X246 [Direct mapping]
Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0023052 [signaling]
Show all
125 aa
13.8 kDa
No 0
DLGAP4-005
ENSP00000363023
ENST00000373913
Q9Y2H0 [Direct mapping]
Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0023052 [signaling]
GO:0045202 [synapse]
Show all
989 aa
107.6 kDa
No 0
DLGAP4-007
ENSP00000363014
ENST00000373907
Q9Y2H0 [Direct mapping]
Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0023052 [signaling]
Show all
992 aa
108 kDa
No 0
DLGAP4-008
ENSP00000345700
ENST00000340491
Q9Y2H0 [Direct mapping]
Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0023052 [signaling]
Show all
453 aa
49.5 kDa
No 0
DLGAP4-009
ENSP00000477723
ENST00000475894
A0A0B4J2C2 [Direct mapping]
Discs, large (Drosophila) homolog-associated protein 4, isoform CRA_b; Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0023052 [signaling]
Show all
285 aa
31.7 kDa
No 0
DLGAP4-011
ENSP00000480166
ENST00000482872
A0A087WWE6 [Direct mapping]
Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
46 aa
4.9 kDa
No 0
DLGAP4-015
ENSP00000419311
ENST00000489701
F8WF49 [Direct mapping]
Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0023052 [signaling]
Show all
244 aa
26.9 kDa
No 0
DLGAP4-201
ENSP00000341633
ENST00000339266
Q9Y2H0 [Direct mapping]
Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0023052 [signaling]
Show all
992 aa
108 kDa
No 0
DLGAP4-202
ENSP00000384954
ENST00000401952
Q9Y2H0 [Direct mapping]
Disks large-associated protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0023052 [signaling]
Show all
989 aa
107.6 kDa
No 0

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