Expression of STK17B in cancer - Summary - The Human Protein Atlas

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STK17B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STK17B
Gene description	Serine/threonine kinase 17b
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA034858
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034858

GENE INFORMATION
Gene name	STK17B (HGNC Symbol)
Synonyms	DRAK2
Description	Serine/threonine kinase 17b (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q32.3
Chromosome location (bp)	196133566 - 196176503
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000081320 (version 83.38)
Entrez gene	9262
UniProt	O94768 (UniProt - Evidence at protein level)
neXtProt	NX_O94768
Antibodypedia	STK17B antibodies

PROTEIN BROWSER

STK17B-001	STK17B-002	STK17B-003	STK17B-004	STK17B-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STK17B-001 ENSP00000263955 ENST00000263955	O94768 [Direct mapping] Serine/threonine-protein kinase 17B Q53QE7 [Target identity:100%; Query identity:100%] Putative uncharacterized protein STK17B; Serine/threonine kinase 17b (Apoptosis-inducing); cDNA, FLJ93309, Homo sapiens serine/threonine kinase 17b (apoptosis-inducing) (STK17B), mRNA Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0012501 [programmed cell death] GO:0015629 [actin cytoskeleton] GO:0035556 [intracellular signal transduction] GO:0046777 [protein autophosphorylation] GO:2000271 [positive regulation of fibroblast apoptotic process] Show all	372 aa 42.3 kDa	No	1
STK17B-002 ENSP00000386853 ENST00000409228	O94768 [Direct mapping] Serine/threonine-protein kinase 17B Q53QE7 [Target identity:100%; Query identity:100%] Putative uncharacterized protein STK17B; Serine/threonine kinase 17b (Apoptosis-inducing); cDNA, FLJ93309, Homo sapiens serine/threonine kinase 17b (apoptosis-inducing) (STK17B), mRNA Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] GO:0046777 [protein autophosphorylation] GO:2000271 [positive regulation of fibroblast apoptotic process] Show all	372 aa 42.3 kDa	No	1
STK17B-003 ENSP00000399755 ENST00000420683	C9JZJ1 [Direct mapping] Serine/threonine-protein kinase 17B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	67 aa 7.8 kDa	No	0
STK17B-004 ENSP00000413289 ENST00000449152		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.9 kDa	No	0
STK17B-005 ENSP00000475843 ENST00000606789	U3KQF8 [Direct mapping] Serine/threonine-protein kinase 17B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	69 aa 8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.