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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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LRP2
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

LRP2

Gene description

Low density lipoprotein receptor-related protein 2

Protein class

Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (breast cancer, renal cancer, thyroid cancer)
HPA (cell line):Group enriched (AF22, CACO-2)
HPA (normal tissue):Group enriched (kidney, parathyroid gland, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression mainly in renal tubules and parathyroid gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA005980 , HPA064792
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (breast cancer, renal cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA005980
HPA064792

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong cytoplasmic staining was observed in most renal cancers. Remaining cancers were mainly negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of renal cancer showed weak to moderate membranous and cytoplasmic positivity. A single case of breast cancer showed moderate luminal membranous and cytoplasmic positivity. Remaining cancers were weakly stained or negative.

GENE INFORMATION

Gene name

LRP2 (HGNC Symbol)

Synonyms

DBS, gp330

Description

Low density lipoprotein receptor-related protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]

Chromosome

2

Cytoband

q31.1

Chromosome location (bp)

169127109 - 169362685

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000081479 (version 83.38)

Entrez gene

4036

UniProt

P98164 (UniProt - Evidence at protein level)

neXtProt

NX_P98164

Antibodypedia

LRP2 antibodies

PROTEIN BROWSER

LRP2-001
LRP2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRP2-001
ENSP00000263816
ENST00000263816
P98164 [Direct mapping]
Low-density lipoprotein receptor-related protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0003281 [ventricular septum development]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005905 [coated pit]
GO:0006486 [protein glycosylation]
GO:0006629 [lipid metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007507 [heart development]
GO:0007603 [phototransduction, visible light]
GO:0008202 [steroid metabolic process]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0017124 [SH3 domain binding]
GO:0017147 [Wnt-protein binding]
GO:0030139 [endocytic vesicle]
GO:0030900 [forebrain development]
GO:0031526 [brush border membrane]
GO:0035904 [aorta development]
GO:0042359 [vitamin D metabolic process]
GO:0042813 [Wnt-activated receptor activity]
GO:0043235 [receptor complex]
GO:0044281 [small molecule metabolic process]
GO:0044332 [Wnt signaling pathway involved in dorsal/ventral axis specification]
GO:0045177 [apical part of cell]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060976 [coronary vasculature development]
GO:0070062 [extracellular exosome]
Show all
4655 aa
522 kDa
Yes 1
LRP2-005
ENSP00000409813
ENST00000443831
E9PC35 [Direct mapping]
Low-density lipoprotein receptor-related protein 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
GO:0017147 [Wnt-protein binding]
GO:0042813 [Wnt-activated receptor activity]
GO:0044332 [Wnt signaling pathway involved in dorsal/ventral axis specification]
GO:0060070 [canonical Wnt signaling pathway]
Show all
1225 aa
136.2 kDa
Yes 0

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