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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PHLPP1
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PHLPP1

Gene description

PH domain and leucine rich repeat protein phosphatase 1

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
HPA020200
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA020200

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of breast and prostate cancers were strongly stained. Cancers cells in general displayed weak to moderate staining. Cervical, endometrial, skin and lung cancers were mainly negative.

GENE INFORMATION

Gene name

PHLPP1 (HGNC Symbol)

Synonyms

KIAA0606, PHLPP, PLEKHE1, SCOP

Description

PH domain and leucine rich repeat protein phosphatase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]

Chromosome

18

Cytoband

q21.33

Chromosome location (bp)

62715450 - 62980433

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000081913 (version 83.38)

Entrez gene

23239

UniProt

O60346 (UniProt - Evidence at protein level)

neXtProt

NX_O60346

Antibodypedia

PHLPP1 antibodies

PROTEIN BROWSER

PHLPP1-001
PHLPP1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHLPP1-001
ENSP00000262719
ENST00000262719
O60346 [Direct mapping]
PH domain leucine-rich repeat-containing protein phosphatase 1
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Enzymes
   ENZYME proteins
   Hydrolases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002667 [regulation of T cell anergy]
GO:0003824 [catalytic activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009649 [entrainment of circadian clock]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0045087 [innate immune response]
GO:0046328 [regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:1900744 [regulation of p38MAPK cascade]
Show all
1717 aa
184.7 kDa
No 0
PHLPP1-004
ENSP00000467279
ENST00000591386
K7EP91 [Direct mapping]
PH domain leucine-rich repeat-containing protein phosphatase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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198 aa
22.5 kDa
No 0

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